FB2026_02 , released June 18, 2026
Allele: Dmel\hiwunspecified
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General Information
Symbol
Dmel\hiwunspecified
Species
D. melanogaster
Name
FlyBase ID
FBal0125005
Feature type
allele
Associated gene
Dmel\hiw
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description

    FlyBase curator comment: this entry is used to capture phenotypic information when the particular allele (or allele combination) used by the author could not be determined but the context of the experiment suggests that the phenotype being described is some kind of loss of function.

    (FlyBase Curators, 2025-)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        hiwunspecified loss of function alleles show a large increase in the number of synaptic branches, and synaptic span, a small decrease in quantal size and a large decrease in quantal content.

        (DiAntonio et al., 2001)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Enhanced by
        Suppressed by
        Statement
        Reference

        hiwunspecified has synaptic vesicle phenotype, suppressible by fafBX4

        (DiAntonio et al., 2001)

        hiwunspecified has synaptic vesicle phenotype, suppressible by fafFO8/fafBX4

        (DiAntonio et al., 2001)
        NOT suppressed by
        Statement
        Reference

        hiwunspecified has synapse phenotype, non-suppressible by fafFO8/fafBX4

        (DiAntonio et al., 2001)

        hiwunspecified has synapse phenotype, non-suppressible by fafBX4

        (DiAntonio et al., 2001)
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        The addition of either homozygous fafBX4, or fafBX4/fafFO8 suppresses the physiological phenotype of hiwunspecified, leading to a more tha doubling of both quantal content and mEJP frequency. However the synaptic overgrowth phenotype is not affected. The addition off GluRIIAM614R.Scer\UAS.T:Hsap\MYC to hiw mutants leads to a an 18% decrease in quantal size, no change in the size of the evoked response, and a compensatory 30% increase in quantal content.

        (DiAntonio et al., 2001)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        hiwunspecified
        Name Synonyms
        Secondary FlyBase IDs
          References (3)