FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\hbeve.st2ΔKr
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General Information
Symbol
Dmel\hbeve.st2ΔKr
Species
D. melanogaster
Name
FlyBase ID
FBal0126377
Feature type
allele
Associated gene
Dmel\hb
Associated Insertion(s)
Carried in Construct
P{eve(-FRT)hb.st2ΔKr}
Key Links
Transgenic product class
wild_type
(Wu et al., 2001)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Wu et al., 2001)
Mutagen
in vitro construct
(Wu et al., 2001)
Progenitor genotype
hbFRT.eve.st2ΔKr
(Wu et al., 2001)
Carried in construct
P{eve(-FRT)hb.st2ΔKr}
Cytology
Description

The FRT cassette has ben excised, juxtaposing the mutated eve stripe 2 enhancer sequences with the hb coding sequences.

(Wu et al., 2001)
Allele components
Component
Use(s)
Regulatory region(s)
eve
Encoded product / tool
hb
Also carries
FRT
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      hbeve.st2ΔKr is a suppressor of lethal phenotype of kni2FKE.eve

      (Wu et al., 2001)
      Phenotype Manifest In
      Suppressed by
      Statement
      Reference

      hb12, hbeve.st2ΔKr has larval head phenotype, suppressible by Krunspecified

      (Wu et al., 2001)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The addition of hbeve.st2ΔKr to kni2FKE.eve animals fully rescues the lethality phenotype. The addition of Krunspecified to hb12, hbeve.st2ΔKr animals causes a dramatic rescue of most head structure defects, and a few embryos (about 10%) show anterior phenotypes that are indistinguishable from wild-type.

      (Wu et al., 2001)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      hbeve.st2ΔKr partially rescues hb12

      (Wu et al., 2001)
      Comments

      Addition of hbeve.st2ΔKr to hb12 mutants specifically rescues the prothorax and returns A1 to its normal size. Rescue with two copies of the transgene further increases the size of the thorax and rescues the dorsal part of T3. T2, however is never present in these embryos. hbeve.st2ΔKr causes a very weak rescue of the head structure defects.

      (Wu et al., 2001)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      hbeve.st2ΔKr
      Name Synonyms
      Secondary FlyBase IDs
        References (1)