FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\fry2
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General Information
Symbol
Dmel\fry2
Species
D. melanogaster
Name
FlyBase ID
FBal0126391
Feature type
allele
Associated gene
Dmel\fry
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Cong et al., 2001)
Progenitor genotype
Cytology
Description

Amino acid replacement: ?2299term.

(Cong et al., 2001)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3L:9,636,911..9,636,911 [-]
Nucleotide change:

C9636911T

Amino acid change:

Q2299term | fry-PB; Q2347term | fry-PC; Q2342term | fry-PE; Q2299term | fry-PF; Q2347term | fry-PG; Q2294term | fry-PH; Q2347term | fry-PI; Q2299term | fry-PJ

Reported amino acid change:

?2299term

Comment:

Position of mutation on reference sequence inferred by FlyBase curator based on author statement. Author mapped mutation reletige to a 3479aa fry isoform.

(Cong et al., 2001)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of fryUAS.Tag:MYC.GFP under the control of Scer\GAL4Act.PU completely rescues the lethality of fry1/fry2 mutants. These rescued flies are both male and female sterile. The paired ovaries of rescued females are often of different sizes, and the eggs produced are more rounded than normal and are rarely laid. Wing cells in adult wings from these rescued flies display (in 99% of cases) a single hair compared to the more than four hairs per cell seen in fry loss of function clones.

      (Fang et al., 2010)

      Cells in homozygous clones in the wing form a cluster of hairs. The phenotype is cell autonomous.

      (Cong et al., 2001)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Other
      Statement
      Reference

      fry2/fry[+], matse235, trc1/trc[+] has visible | dominant phenotype

      (He et al., 2005)

      fry2/fry[+], matse03077, trc1/trc[+] has visible | dominant phenotype

      (He et al., 2005)
      Phenotype Manifest In
      Other
      Statement
      Reference

      fry2/fry[+], matse235, trc1/trc[+] has wing hair | increased number phenotype

      (He et al., 2005)

      fry2/fry[+], matse03077, trc1/trc[+] has wing hair | increased number phenotype

      (He et al., 2005)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      fry2 trc1 matse235 triple heterozygotes have a weak multiple wing hair phenotype in 48% of wings.

      (He et al., 2005)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescued by

      fry2/fry1 is partially rescued by Scer\GAL4Act.PU/fryUAS.Tag:MYC.GFP

      (Fang et al., 2010)
      Not rescued by

      fry2/fry1 is not rescued by Scer\GAL4Act.PU/fry1637.UAS.Tag:MYC

      (Fang et al., 2010)
      Comments

      Expression of fryUAS.Tag:MYC.GFP under the control of Scer\GAL4Act.PU completely rescues the lethality of fry1/fry2 mutants. These rescued flies are both male and female sterile. The paired ovaries of rescued females are often of different sizes, and the eggs produced are more rounded than normal and are rarely laid. Wing cells in adult wings from these rescued flies display (in 99% of cases) a single hair compared to the more than four hairs per cell seen in fry loss of function clones.

      (Fang et al., 2010)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      fry2
      (Fang et al., 2010, He et al., 2005)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)