FB2026_02 , released June 18, 2026
Allele: Dmel\btz2
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General Information
Symbol
Dmel\btz2
Species
D. melanogaster
Name
FlyBase ID
FBal0126449
Feature type
allele
Associated gene
Dmel\btz
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

amorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(van Eeden et al., 2001)
Mutagen
Delta2-3 transposase
(van Eeden et al., 2001)
Progenitor genotype
P{PZ}btzrL203
(van Eeden et al., 2001)
Cytology
Description

Contains a deletion of the first 1221 nts of btz removing the N terminal 332 amino acids.

(van Eeden et al., 2001)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Embryos derived from hemizygous btz2 females have almost wild-type posterior patterning.

      (Snee et al., 2007)

      In stage 9 oocytes from btz2 homozygous germline clones, the accumulation of microtubule plus ends in the posterior of the oocyte fails to occur.

      (Zimyanin et al., 2007)

      Ooplasmic streaming is normal at stage 9 and stage 10b in oocytes derived from homozygous female germline clones.

      (Palacios and St. Johnston, 2002)

      Embryos laid by btz2/Df(3R)IR16 or homozygous mutant mothers lack pole cells and develop an average of about 5 denticle belts. In btz2 Mutant ovaries the arrangement of microtubules appears normal.

      (van Eeden et al., 2001)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      btz2 is an enhancer of partially lethal - majority die | embryonic stage phenotype of BicDD

      (Navarro et al., 2004)
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      btz[+]/btz2 is an enhancer of ventral denticle belt | germline clone phenotype of Ge-1Δ5

      (Fan et al., 2011)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      btz2/+ increases the penetrance of the posterior patterning phenotype of embryos derived from Ge-1Δ5 female germline clones from 4% to 28.8%.

      (Fan et al., 2011)

      BicDD/btz2 double mutants exhibit a hatch-rate of 24%, compared to a hatch-rate of 60% in BicDD control strains. This decrease in hatch-rate indicates an enhancement of the BicDD phenotype by btz2.

      (Navarro et al., 2004)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      References (11)