FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\VAChT2
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General Information
Symbol
Dmel\VAChT2
Species
D. melanogaster
Name
FlyBase ID
FBal0126460
Feature type
allele
Associated gene
Dmel\VAChT
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Kitamoto et al., 2000)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous and VAChT1/VAChT2 larvae are inactive. Approximately 65% of homozygotes die as first instar larvae and 35% die as second instar larvae. Short-latency responses to a single stimulation of the giant fiber are observed in the dorsal longitudinal muscle (DLM) and tergotrochanteral muscle (TTM) of heterozygous flies. The refractory periods are not significantly different from wild type. After a high-frequency tetanic stimulation before the test stimulus, the response of the TTM remains intact but the none or only a few responses are detected in the DLM of heterozygous flies.

      (Kitamoto et al., 2000)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT suppressed by
      Statement
      Reference

      VAChT2/Df(3R)Cha5 has lethal phenotype, non-suppressible by ChATm7.4

      (Kitamoto et al., 2000)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      VAChT1

      (Kitamoto et al., 2000)
      Rescued by

      VAChT2/Df(3R)Cha5 is rescued by VAChT+mKa

      (Kitamoto et al., 2000)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      VAChT2
      Vacht2
      (Nemat et al., 2025, White et al., 2020, Kitamoto et al., 2000)
      l(1)91CD333
      (Kitamoto et al., 2000)
      Name Synonyms
      Secondary FlyBase IDs
        References (4)