FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Tak14
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General Information
Symbol
Dmel\Tak14
Species
D. melanogaster
Name
FlyBase ID
FBal0126472
Feature type
allele
Associated gene
Dmel\Tak1
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Vidal et al., 2001)
Progenitor genotype
Cytology
Description

The lesion is in the kinase domain and results in a dominant-negative protein being produced.

(Geuking et al., 2005)

Amino acid replacement: R257H.

(Vidal et al., 2001)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
X:20,522,361..20,522,361 [-]
Nucleotide change:

G20522361A

Amino acid change:

R257H | Tak1-PA

Reported amino acid change:

R257H

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Vidal et al., 2001)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Tak14 mutant larvae do not exhibit a melanotic phenotype in the posterior hindgut either under normal food conditions or when raised on food containing 0.1M or 0.2M NaCl.

      (Seisenbacher et al., 2011)

      Flies are susceptible to Gram-negative bacterial infection.

      (Vidal et al., 2001)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      Tak14 is a suppressor | partially of melanotic mass phenotype | larval stage | nutrition conditional phenotype of MAPk-Ak2Δ43

      (Seisenbacher et al., 2011)

      Tak1[+]/Tak14 is a suppressor of visible phenotype of Scer\GAL4GMR.PF, egrUAS.cMa

      (Geuking et al., 2005)
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      Tak14 is a suppressor | partially of embryonic/larval hindgut | posterior | larval stage | nutrition conditional phenotype of MAPk-Ak2Δ43

      (Seisenbacher et al., 2011)

      Tak1[+]/Tak14 is a suppressor of eye phenotype of Scer\GAL4GMR.PF, egrUAS.cMa

      (Geuking et al., 2005)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Tak14 partially suppresses the "black dot" phenotype seen in the hindgut of MAPk-Ak2Δ43 larvae raised on either 0.1M or 0.2M NaCl.

      (Seisenbacher et al., 2011)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      TAK14
      (Seisenbacher et al., 2011)
      Tak14
      dTAK14
      (Geuking et al., 2005)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)