FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
Allele: Dmel\tko25t-H85L.tTa
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General Information
Symbol
Dmel\tko25t-H85L.tTa
Species
D. melanogaster
Name
FlyBase ID
FBal0127869
Feature type
allele
Associated gene
Dmel\tko
Associated Insertion(s)
Carried in Construct
P{tko25t-H85L.tTa}
Key Links
Transgenic product class
genomic_DNA
(Toivonen et al., 2001)
wild_type
(Toivonen et al., 2001)
Mutagen
Nature of the Allele
Transgenic product class
genomic_DNA
(Toivonen et al., 2001)
wild_type
(Toivonen et al., 2001)
Mutagen
in vitro construct
(Toivonen et al., 2001)
Progenitor genotype
Carried in construct
P{tko25t-H85L.tTa}
Cytology
Description

3.2kb BamHI genomic fragment containing the wild-type tko coding sequence and flanking sequences (fragment originally isolated from tko25t mutant flies which carry a L85H amino acid replacement - this mutation has been reverted to the wild-type H85 residue in this transgene).

(Toivonen et al., 2001)
Allele components
Component
Use(s)
Regulatory region(s)
tko
Encoded product / tool
tko
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Flies carrying tko25t-H85L.tTa in a wild-type background do not show bang sensitivity and show no developmental delay.

      (Toivonen et al., 2001)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      tko25t-H85L.tTa rescues tko25t

      (Toivonen et al., 2001)

      tko25t-H85L.tTa rescues tko3

      (Toivonen et al., 2001)
      Comments

      Rescues the developmental delay, male courtship defects and bang sensitive phenotypes seen in tko25t flies.

      (Toivonen et al., 2001)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      tko25t-H85L.tTa
      Name Synonyms
      Secondary FlyBase IDs
        References (1)