FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\comtG8
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General Information
Symbol
Dmel\comtG8
Species
D. melanogaster
Name
FlyBase ID
FBal0128018
Feature type
allele
Associated gene
Dmel\comt
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
gamma ray
(Littleton, 2005.8.1)
Progenitor genotype
Cytology
Description

The premature stop codon truncates the protein at the end of the D1 domain.

(Littleton et al., 2001)

Amino acid replacement: T464term.

(Littleton et al., 2001)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
MNV
X:13,260,867..13,260,869 [+]
Nucleotide change:

ACC13260867TGA

Amino acid change:

T464term | comt-PA; T464term | comt-PB

Reported amino acid change:

T464term

Comment:

The reported Thr to Stop amino acid change (ACC to TAA/G or TGA) requires nucleotide changes at all three postions of the codon. The site of the nucleotide substitution in the mutant was inferred by FlyBase based on the reported amino acid change.

(Littleton et al., 2001)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous mutants die during embryonic and larval stages, although a small percentage survive to pupae.

      (Littleton et al., 2001)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      comtG8
      (Littleton, 2005.8.1)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)