FlyBase Allele Report: Dmel\Flo2[KG00210]

General Information

Symbol

Dmel\Flo2^KG00210

Species

D. melanogaster

Name

FlyBase ID

FBal0128194

Feature type

allele

Associated gene

Dmel\Flo2

Associated Insertion(s)

P{SUPor-P}Flo2^KG00210

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Gene Disruption Project members, 2001-)

Progenitor genotype

Associated Insertion(s)

P{SUPor-P}Flo2^KG00210

Cytology

Description

P{SUPor-P}Flo-2^KG00210 is inserted into exon 5 of the Flo-2 gene.

(Hoehne et al., 2005)

Allele components

Component

Use(s)

Inserted element

P{SUPor-P}

insertional mutagenesis tool

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

X:14,926,821..14,926,821 [-]

(Castillo-Mancho et al., 2024, Hoehne et al., 2005, Gene Disruption Project members, 2001-)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal immune response | larval stage

(Howell et al., 2012)

Phenotype Manifest In

Detailed Description

Statement

Reference

Mutant larvae fail to encapsulate eggs when parasitised by the avirulent L. boulardi wasp strain G486 (no melanisation is seen). Plasmatocytes and lamellocytes are absent from the capsule surrounding the egg.

(Howell et al., 2012)

Homozygous Flo-2^KG00210 mutants display no obvious external morphological phenotype. No structural defects are found in the embryonic nervous system, the outer optic chiasms of the optic lobes, or the central brain including the mushroom bodies and the central complex.

(Hoehne et al., 2005)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Suppressor of

Statement

Reference

Flo2^KG00210 is a suppressor | partially of nephrocyte phenotype of scramb1^{MI01181-GFSTF.0}

(Castillo-Mancho et al., 2024)

Flo2^KG00210 is a suppressor | partially of slit diaphragm phenotype of scramb1^{MI01181-GFSTF.0}

(Castillo-Mancho et al., 2024)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

13065

y¹ P{SUPor-P}Flo2^KG00210

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Flo-2^KG00210

Flo2^KG00210

(Castillo-Mancho et al., 2024, Howell et al., 2012)

flotillin-2^KG00210

(Bharadwaj et al., 2013)

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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