FlyBase Allele Report: Dmel\skl[UAS.cWa]

General Information

Symbol

Dmel\skl^UAS.cWa

Species

D. melanogaster

Name

FlyBase ID

FBal0129070

Feature type

allele

Associated gene

Dmel\skl

Associated Insertion(s)

Carried in Construct

P{UAS-skl.W}

Key Links

Transgenic product class

wild_type

(Wing et al., 2002)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Wing et al., 2002)

Mutagen

in vitro construct

(Wing et al., 2002)

Progenitor genotype

Carried in construct

P{UAS-skl.W}

Cytology

Description

UAS sequences drive expression of skl.

(Wing et al., 2002)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

skl

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

When skl^Scer\UAS.cWa is driven by Scer\GAL4^GMR.PF animals survive to adulthood, and nearly all exhibit normal eye morphology.

(Wing et al., 2002)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Scer\GAL4^GMR.PF, rpr^GMR.PW, skl^UAS.cWa has increased cell death phenotype, suppressible by BacA\p35^UAS.cHa, Scer\GAL4^GMR.PF

(Wing et al., 2002)

Scer\GAL4^GMR.PF, rpr^GMR.PW, skl^UAS.cWa has abnormal eye color phenotype, suppressible by BacA\p35^UAS.cHa, Scer\GAL4^GMR.PF

(Wing et al., 2002)

Scer\GAL4^GMR.PF, grim::rpr^rg.UAS, skl^UAS.cWa has abnormal eye color | heat sensitive phenotype, suppressible by BacA\p35^UAS.cHa, Scer\GAL4^GMR.PF

(Wing et al., 2002)

Scer\GAL4^GMR.PF, grim::rpr^rg.UAS, skl^UAS.cWa has lethal phenotype, suppressible by BacA\p35^UAS.cHa, Scer\GAL4^GMR.PF

(Wing et al., 2002)

Enhancer of

Statement

Reference

skl^UAS.cWa/Scer\GAL4^GMR.PF is an enhancer of abnormal eye color | heat sensitive phenotype of Scer\GAL4^GMR.PF, grim::rpr^rg.UAS

(Wing et al., 2002)

Other

Statement

Reference

Scer\GAL4^GMR.PF, grim::rpr^rg.UAS, skl^UAS.cWa has lethal phenotype

(Wing et al., 2002)

Phenotype Manifest In

Suppressed by

Statement

Reference

Scer\GAL4^GMR.PF, rpr^GMR.PW, skl^UAS.cWa has eye phenotype, suppressible by BacA\p35^UAS.cHa, Scer\GAL4^GMR.PF

(Wing et al., 2002)

Scer\GAL4^GMR.PF, grim::rpr^rg.UAS, skl^UAS.cWa has eye | heat sensitive phenotype, suppressible by BacA\p35^UAS.cHa, Scer\GAL4^GMR.PF

(Wing et al., 2002)

Enhancer of

Statement

Reference

skl^UAS.cWa/Scer\GAL4^GMR.PF is an enhancer of eye | heat sensitive phenotype of Scer\GAL4^GMR.PF, grim::rpr^rg.UAS

(Wing et al., 2002)

Additional Comments

Genetic Interactions

Statement

Reference

The addition of skl^Scer\UAS.cWa, to grim::rpr^rg.Scer\UAS, Scer\GAL4^GMR.PF animals leads to complete lethality. At 18^oC there are a few escapers that exhibit severe eye loss of eye tissue. The subsequent addition of BacA\p35^Scer\UAS.cHa represses these phenotypes: The animals are viable and eyes exhibit essentially normal eye size and pigmentation. The addition of skl^Scer\UAS.cWa (driven by Scer\GAL4^GMR.PF) to rpr^GMR.PW flies enhances the eye phenotype. Flies exhibit much more severe eye cell death, with greatly reduced size and pigmentation. The subsequent addition of BacA\p35^Scer\UAS.cHa represses these phenotypes.

(Wing et al., 2002)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

skl^Scer\UAS.cWa

skl^UAS.cWa

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

Open Close