FlyBase Allele Report: Dmel\skl[UAS.cSa]

General Information

Symbol

Dmel\skl^UAS.cSa

Species

D. melanogaster

Name

Saccharomyces cerevisiae UAS construct a of Srinivasula

FlyBase ID

FBal0129071

Feature type

allele

Associated gene

Dmel\skl

Associated Insertion(s)

Carried in Construct

P{UAS-skl.S}

Also Known As

UAS-sickle

Key Links

Transgenic product class

wild_type

(Srinivasula et al., 2002)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Srinivasula et al., 2002)

Mutagen

in vitro construct

(Srinivasula et al., 2002, Srinivasula et al., 2002)

Progenitor genotype

Carried in construct

P{UAS-skl.S}

Cytology

Description

UAS sequences drive expression of skl.

(Srinivasula et al., 2002)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

skl

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

increased cell death, with Scer\GAL4^GMR.PF

(Srinivasula et al., 2002)

Phenotype Manifest In

eye, with Scer\GAL4^GMR.PF

(Srinivasula et al., 2002)

Detailed Description

Statement

Reference

When skl^Scer\UAS.cSa is driven by Scer\GAL4^GMR.PF an increase in cell death is seen in the eye imaginal disc leading to smaller than wild-type eye.

(Srinivasula et al., 2002)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Scer\GAL4^GMR.PF, skl^UAS.cSa has increased cell death phenotype, enhanceable by grim^GMR.PC

(Srinivasula et al., 2002)

Suppressor of

Statement

Reference

skl^UAS.cSa/Scer\GAL4^vg.PM is a suppressor | partially of lethal | pupal stage phenotype of Scer\GAL4^vg.PM, stwl^UY823

(Brun et al., 2006)

Phenotype Manifest In

Enhanced by

Statement

Reference

Scer\GAL4^GMR.PF, skl^UAS.cSa has eye phenotype, enhanceable by grim^GMR.PC

(Srinivasula et al., 2002)

Additional Comments

Genetic Interactions

Statement

Reference

No wing phenotypes are seen when skl^Scer\UAS.cSa under the control of Scer\GAL4^azot-GAL4 in azot^KO.GAL4/azot^KO mutant flies, either with or without exposure to radiation.

(Merino et al., 2015)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Carried in a plasmid and transiently transfected into S2 cells in order to study the effect of skl of apoptosis.

(Srinivasula et al., 2002)

Carried in a plasmid and transiently transfected into S2 cells in order to study the effect of skl on apoptosis.

(Srinivasula et al., 2002)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

skl^Scer\UAS.cSa

skl^UAS.cSa

Name Synonyms

Saccharomyces cerevisiae UAS construct a of Srinivasula

(Srinivasula et al., 2002, Srinivasula et al., 2002)

Secondary FlyBase IDs

References (4)

Report Sections

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