FB2026_02 , released June 18, 2026
Allele: Dmel\Sirt1EP2384
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General Information
Symbol
Dmel\Sirt1EP2384
Species
D. melanogaster
Name
FlyBase ID
FBal0130598
Feature type
allele
Associated gene
Dmel\Sirt1
Associated Insertion(s)
P{EP}Sirt1EP2384
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Gene Disruption Project members, 2001-, FlyBase, 1996-)
Progenitor genotype
Associated Insertion(s)
P{EP}Sirt1EP2384
Cytology
Description

The P{EP}Sir2EP2384 insertion maps within both Sir2 and DnaJ-H (overlapping genes on opposite strands).

(FlyBase, 1996-)
Allele components
Component
Use(s)
Inserted element
P{EP}
Regulatory region(s)
UAS
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Sir2EP2384; Scer\GAL4αTub84B.PL females live on average 44% longer than controls and have a maximal life span (mean of 10% survival) of 25% longer than controls. For males of this genotype, the equivalent figures are 14% and 21% respectively.

      (Rogina and Helfand, 2004)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Sir2EP2384
      Sirt1EP2384
      dSir2EP2384
      (Rogina and Helfand, 2004)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)