FlyBase Allele Report: Dmel\Etl1[EP701]

General Information

Symbol

Dmel\Etl1^EP701

Species

D. melanogaster

Name

FlyBase ID

FBal0131455

Feature type

allele

Associated gene

Dmel\Etl1

Associated Insertion(s)

P{EP}Etl1^EP701

Carried in Construct

Also Known As

EP701

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Gene Disruption Project members, 2001-)

Progenitor genotype

Associated Insertion(s)

P{EP}Etl1^EP701

Cytology

Description

Insertion at nucleotide position +587 relative to the transcription start site.

(Schneiderman et al., 2009)

Allele components

Component

Use(s)

Inserted element

P{EP}

misexpression element

Regulatory region(s)

UAS

binary expression system - regulatory region

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

2L:9,911,998..9,911,998 [-]

(Schneiderman et al., 2010, Schneiderman et al., 2009, Stofanko et al., 2008, van Swinderen and Greenspan, 2005, Gene Disruption Project members, 2001-)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

suppressor of variegation, with Dp(?;2)bw^D, Scer\GAL4^GMR.PF

(Schneiderman et al., 2009)

Phenotype Manifest In

embryonic/larval hemocyte | third instar larval stage, with Scer\GAL4^Pxn.PS

(Stofanko et al., 2008)

Detailed Description

Statement

Reference

Expression of CG5899^EP701 under the control of Scer\GAL4^GMR.PF increases the eye pigmentation in Dp(?;2)bw^D/bw[+] animals.

(Schneiderman et al., 2009)

Third instar larvae expressing Etl1^EP701 under the control of Scer\GAL4^Pxn.PS have an increased number of sessile hemocytes. The number of hemocytes in circulation is also increased. The dorsal sessile hemocyte department is not disrupted. Sessile hemocytes do not accumulate along the dorsal vessel or spread through the cuticle. The lymph gland is not enlarged. Hemocyte shape is normal.

(Stofanko et al., 2008)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Etl1^EP701/Scer\GAL4^GMR.PF is a suppressor of abnormal eye color | dominant phenotype of bw^D

(Schneiderman et al., 2010)

Etl1^EP701/CG5899[+] is a suppressor of uncoordinated | dominant | heat sensitive phenotype of Syx1A^3-69

(van Swinderen and Greenspan, 2005)

Phenotype Manifest In

Suppressor of

Statement

Reference

Etl1^EP701/Scer\GAL4^GMR.PF is a suppressor of eye phenotype of bw^D

(Schneiderman et al., 2010)

Additional Comments

Genetic Interactions

Statement

Reference

Mis-expression of Etl1^EP701 driven by Scer\GAL4^GMR.PF results in increased eye pigmentation in bw^D/+ heterozygotes compared with that in the parental bw^D/+ line.

(Schneiderman et al., 2010)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

CG5899^EP701

Etl1^EP701

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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