FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Atg8aEP362
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General Information
Symbol
Dmel\Atg8aEP362
Species
D. melanogaster
Name
FlyBase ID
FBal0131597
Feature type
allele
Associated gene
Dmel\Atg8a
Associated Insertion(s)
P{EP}Atg8aEP362
Carried in Construct
Also Known As
Atg8a1, UAS-Atg8a
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Gene Disruption Project members, 2001-)
Progenitor genotype
Associated Insertion(s)
P{EP}Atg8aEP362
Cytology
Description
Allele components
Component
Use(s)
Inserted element
P{EP}
Regulatory region(s)
UAS
Mutations Mapped to the Genome
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Atg8aEP362 homozygous adults are sensitive to acute food deprivation.

      (Bourouis et al., 2019)

      Wild-type flies show age-induced memory impairment which can be ameliorated by spermidine-feeding. In contrast to wild-type, homozygous female Atg8aEP362 flies show reduced memory performance at both young (3 days of age) and old age (20 days), even with spermidine administration.

      (Gupta et al., 2013)

      Mutant males have a shortened adult life span compared to controls, with a mean life span of 41.9 days at 25o.

      (Simonsen et al., 2007)

      Viable. No effect on autophagy.

      (Scott et al., 2004)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      NOT Suppressor of
      Statement
      Reference

      Atg8a[+]/Atg8aEP362 is a non-suppressor of decreased size | adult stage phenotype of Scer\GAL4ey.PH, mir-137UAS.cSb

      (Padma et al., 2025)
      Phenotype Manifest In
      Suppressor of
      NOT Suppressor of
      Statement
      Reference

      Atg8a[+]/Atg8aEP362 is a non-suppressor of eye phenotype of Scer\GAL4ey.PH, mir-137UAS.cSb

      (Padma et al., 2025)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Atg8aEP362/+ suppresses the loss of pigmentation and partially suppresses loss of bristles in flies with expression of Hsap\BCL2L13Scer\UAS.cNa driven by Scer\GAL4GMR.PS. Presence of Atg8aEP362 in Scer\GAL4GMR.PS>Hsap\BCL2L13ΔTM.Scer\UAS flies does not result in significant eye phenotypes.

      (Nakazawa et al., 2016)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (5)
      References (16)