FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\sanKG04816
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General Information
Symbol
Dmel\sanKG04816
Species
D. melanogaster
Name
FlyBase ID
FBal0133998
Feature type
allele
Associated gene
Dmel\san
Associated Insertion(s)
P{SUPor-P}sanKG04816
Carried in Construct
Also Known As
san2
Key Links
Genomic Maps

Allele class

amorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Williams et al., 2003)
Mutagen
P-element activity
(Gene Disruption Project members, 2001-)
Progenitor genotype
Associated Insertion(s)
P{SUPor-P}sanKG04816
Cytology
Description

Insertion of a P-element into the 5' UTR.

(Williams et al., 2003)
Allele components
Component
Use(s)
Inserted element
P{SUPor-P}
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Mutant flies show significantly increased survival compared to wild-type flies after infection with E. chaffeensis. Bacterial replication is significantly reduced in the mutant flies compared to wild type.

      (Von Ohlen et al., 2012)

      Homozygous clones in the follicle cells are significantly smaller and recovered less frequently than control clones.

      (Pimenta-Marques et al., 2008)

      Homozygous larval brains show a reduced mitotic index (0.13) compared to wild type (1.04). 100% of the mitotic cells are in prometaphase/metaphase compared to 88% in wild type. 92% of mitotic cells have overcondensed chromosomes and 95% of prometaphase/metaphase cells show precocious sister chromatid separation (PSCS). san1/sanKG04816 larval brains show a reduced mitotic index (0.48) compared to wild type (1.04). 91% of the mitotic cells are in prometaphase/metaphase compared to 88% in wild type. 100% of anaphases show abnormalities, 68% of mitotic cells have overcondensed chromosomes and 82% of prometaphase/metaphase cells show precocious sister chromatid separation (PSCS).

      (Williams et al., 2003)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      NOT Enhancer of
      Statement
      Reference

      san[+]/sanKG04816 is a non-enhancer of wing margin phenotype of ctK

      (Dorsett et al., 2005)
      NOT Suppressor of
      Statement
      Reference

      san[+]/sanKG04816 is a non-suppressor of wing margin phenotype of ctK

      (Dorsett et al., 2005)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      sanKG04816 heterozygosity does not affect the wing margin nick phenotype of ctK mutants.

      (Dorsett et al., 2005)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      san2
      (Pimenta-Marques et al., 2008, Dorsett et al., 2005, Williams et al., 2003)
      sanKG04816
      spanKG04816
      Name Synonyms
      Secondary FlyBase IDs
        References (5)