FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Ork1Δ-NC.UAS.EGFP
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General Information
Symbol
Dmel\Ork1Δ-NC.UAS.EGFP
Species
D. melanogaster
Name
FlyBase ID
FBal0135890
Feature type
allele
Associated gene
Dmel\Ork1
Associated Insertion(s)
Carried in Construct
P{UAS-Ork1.Δ-NC}
Also Known As
UAS-dORKΔ-NC, UAS-dORK1.ΔNC
Key Links
Transgenic product class
missense_variant
(Nitabach et al., 2002)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Nitabach et al., 2002)
Mutagen
in vitro construct
(Nitabach, 2002.5.23, Nitabach et al., 2002)
Progenitor genotype
Carried in construct
P{UAS-Ork1.Δ-NC}
Cytology
Description

Encodes a non-conducting form of Ork1; carries the amino acid replacements G107A, Y108A, G109A, G219A, F220A and G221A.

(Nitabach et al., 2002)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Ork1
Tagged with
EGFP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Flies expressing Ork1Δ-NC.Scer\UAS.T:Avic\GFP-EGFP in dorsomedial lateral ventral subset LNv neurons, under the regulation of Scer\GAL4P2.4.Pdf exhibit steady, free-running circadian rhythms of locomotor activity with a single statistically significant period of approximately 24.5 hrs, as in wild-type.

      (Nitabach et al., 2006)

      Expression of Ork1Δ-NC.Scer\UAS.T:Avic\GFP-EGFP in all larval clock neurons (four LNs plus approximately 8 other neurons in each lobe) under the control of Scer\GAL4tim.Scer\UAS results in larvae that do not display photophobic behaviour.

      (Mazzoni et al., 2005)

      Only 3% of flies expressing Ork1Δ-NC.Scer\UAS.T:Avic\GFP-EGFP under the control of Scer\GAL4P2.4.Pdf are arrhythmic with respect to free-running locomotor activity. In LD conditions, flies expressing Ork1Δ-NC.Scer\UAS.T:Avic\GFP-EGFP under the control of Scer\GAL4P2.4.Pdf begin to increase their activity about 2 hours before lights-off (as do wild-type flies).

      (Nitabach et al., 2002)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Suppressor of
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Expression of Hsap\KCNJ2Scer\UAS.T:Avic\GFP-EGFP with Ork1Δ-NC.Scer\UAS.T:Avic\GFP-EGFP, under the control of Scer\GAL4P2.4.Pdf induces behavioural arrhythmicity in over 60% of flies.

      (Nitabach et al., 2006)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Ork1Δ-NC.Scer\UAS.T:Avic\GFP-EGFP
      Ork1Δ-NC.Scer\UAS.T:Avic\GFP-F64L.S65T
      Ork1Δ-NC.UAS.EGFP
      Name Synonyms
      Secondary FlyBase IDs
        References (12)