FlyBase Allele Report: Dmel\DNAlig4[EP385]

General Information

Symbol

Dmel\DNAlig4^EP385

Species

D. melanogaster

Name

FlyBase ID

FBal0136135

Feature type

allele

Associated gene

Dmel\DNAlig4

Associated Insertion(s)

P{EP}DNAlig4^EP385

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Pena-Rangel et al., 2002)

Progenitor genotype

Associated Insertion(s)

P{EP}DNAlig4^EP385

Cytology

Description

Insertion site is 38 bp upstream of the ATG start codon of the Lig4 gene.

(Gorski et al., 2003)

Allele components

Component

Use(s)

Inserted element

P{EP}

misexpression element

Regulatory region(s)

UAS

binary expression system - regulatory region

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

X:13,667,788..13,667,788 [-]

(McVey et al., 2004, Gorski et al., 2003, Pena-Rangel et al., 2002)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

radiation sensitive | embryonic stage

(Gorski et al., 2003)

Phenotype Manifest In

Detailed Description

Statement

Reference

Lig4^EP385 hemizygotes have limited hypersensitivity to X rays as embryos, but not as larvae (the ratio of hemizygous males to heterozygous female siblings from irradiated embryos is 0.895 compared to 1.08 for controls.)

(Gorski et al., 2003)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Scer\GAL4^pnr-MD237/DNAlig4^EP385 is an enhancer of visible phenotype of pnr^MD237

(Pena-Rangel et al., 2002)

Phenotype Manifest In

Other

Statement

Reference

DNAlig4^EP385, Scer\GAL4^pnr-MD237, pnr^MD237/pnr[+] has scutellum phenotype

(Pena-Rangel et al., 2002)

DNAlig4^EP385, Scer\GAL4^pnr-MD237, pnr^MD237 has scutellum phenotype

(Pena-Rangel et al., 2002)

Additional Comments

Genetic Interactions

Statement

Reference

pnr^MD237/+ adults expressing Lig4^EP385 under the control of Scer\GAL4^pnr-MD237 do not form a scutellum.

(Pena-Rangel et al., 2002)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

10116

w¹¹¹⁸ P{EP}DNAlig4^EP385

Notes on Origin

Discoverer

Selected as: a P{EP} insertion line that modifies the pnr^MD237/+ phenotype when expressed using Scer\GAL4^pnr-MD237.

(Pena-Rangel et al., 2002)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

CG12176^EP(X)0385

(Gorski et al., 2003)

CG12176^EP385

(Pena-Rangel et al., 2002)

DNAlig4^EP385

Lig4^EP385

ligase4^EP385

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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