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General Information
Symbol
Dmel\exexJJ154
Species
D. melanogaster
Name
FlyBase ID
FBal0137269
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
hb9JJ154
Key Links
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Nucleotide change:

G7950847A

Reported nucleotide change:

G1589A

Amino acid change:

W494term | exex-PA

Reported amino acid change:

W?term

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Nucleotide substitution: G1589A.

The premature stop codon is predicted to result in a truncated protein that lacks the C-terminal 32 amino acids.

Amino acid replacement: W?term.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

68.3% of exexKK30/exexJJ154 mutant anterior dMP2 neurons fail to undergo apoptosis. Other aspects of dMP2 specification appear unaffected; they are able to project neurons posteriorly along the most medial fascicle, and exit the VNC to innervate the hindgut correctly.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments

Expression of exexScer\UAS.cOa from embryonic stage 16 onwards under the control of Scer\GAL4Vap.P0201 fails to rescue the apoptosis defects seen in exexKK30/exexJJ154 mutant anterior dMP2 neurons. Expressing exexScer\UAS.cOa from stage 10 under the control of Scer\GAL4odd-106 does rescue this apoptosis.

Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
Comments
Comments

exex protein is present at wild type levels.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (5)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (5)