FB2026_02 , released June 18, 2026
Allele: Dmel\Sirt1ex10
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General Information
Symbol
Dmel\Sirt1ex10
Species
D. melanogaster
Name
FlyBase ID
FBal0137348
Feature type
allele
Associated gene
Dmel\Sirt1
Associated Insertion(s)
P{?PZ}Sirt1ex10
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Rosenberg and Parkhurst, 2002)
Progenitor genotype
Sirt105327a
(Rosenberg and Parkhurst, 2002)
Associated Insertion(s)
P{?PZ}Sirt1ex10
Cytology
Description

Excision of the P{PZ} element that results in an 8bp duplication and a 30bp insertion that disrupts the Sir2 start site.

(Rosenberg and Parkhurst, 2002)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The position effect variegation of the w gene seen in P{lacW}50C.x6, In(1)wm4 and P{hsp26-pt-T}39C-72 is suppressed in Sir2ex10 heterozygotes. The position effect variegation of the w gene seen in P{hsp26-pt-T}39C-5 and P{hsp26-pt-T}39C-55 is not suppressed in Sir2ex10 heterozygotes. There is a marked decrease from the expected number of male progeny in the progeny of a cross between heterozygous males and females.

      (Rosenberg and Parkhurst, 2002)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Embryos derived from Sir2ex10/+ ; RpII140wimp/+ females (mated to wild-type males) die and show anterior-posterior patterning defects, including loss of segments and pairwise denticle band fusions.

      (Rosenberg and Parkhurst, 2002)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Separable from: a second site recessive lethal mutation.

      (Astrom et al., 2003)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Sir2ex10
      Sirt1ex10
      dsir2ex10
      (Astrom et al., 2003)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)