FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\PGRP-LC2
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General Information
Symbol
Dmel\PGRP-LC2
Species
D. melanogaster
Name
FlyBase ID
FBal0137406
Feature type
allele
Associated gene
Dmel\PGRP-LC
Associated Insertion(s)
Carried in Construct
Also Known As
PGRP2
Key Links
Genomic Maps

Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Choe et al., 2002)
Mutagen
ethyl methanesulfonate
(Choe et al., 2002)
Progenitor genotype
Cytology
Description

Amino acid replacement: ??term.

(Choe et al., 2002)

Stop codon is introduced into the PGRP-LCx isoform, resulting in a truncated protein lacking the last 107 amino acids of this isoform.

(Choe et al., 2002)

Nucleotide substitution: G?A.

(Choe et al., 2002)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3L:9,345,880..9,345,880 [+]
Nucleotide change:

G9345880A

Reported nucleotide change:

G?A

Amino acid change:

W392term | PGRP-LC-PA; W392term | PGRP-LC-PD; W221term | PGRP-LC-PE

Reported amino acid change:

??term

Comment:

Mapped site of nonsense mutation based on report that it removes the last 107 amino acids of isoform PGRP-LCx, which appears to correspond to annotated isoforms PGRP-LC-PA. The G to A change may occur at the second or third base of the Trp codon to give a nonsense mutation. The exact site of mutation was not specified.

(Choe et al., 2002)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Motor neurons in PGRP-LC2/+ third instar larvae show similar mEPSP (mini excitatory postsynaptic potential) and EPSP (excitatory postsynaptic potential) amplitudes and quantal content as controls.

      (Harris et al., 2018)

      The neuromuscular junctions of PGRP-LC2 homozygous mutant third instar larvae present small but significant decreases in spontaneous miniature excitatory postsynaptic potential and in excitatory postsynaptic potential, but no significant changes in quantal content, as compared to controls.

      The neuromuscular junctions of PGRP-LCΔE/PGRP-LC2 transheterozygous mutant third instar larvae present small but significant decrease in spontaneous miniature excitatory postsynaptic potential and increase in quantal content, but no significant effect in the excitatory postsynaptic potential, as compared to controls.

      PGRP-LC2 heterozygosity has no significant effect on either spontaneous miniature excitatory postsynaptic potential, excitatory postsynaptic potential or quantal content of third instar larval neuromuscular junctions, as compared to controls.

      The neuromuscular junction of PGRP-LC2 homozygous mutant third instar larvae shows similar overall structure to controls, with similar number of synaptic boutons, similar number and length of active zones, similar average vesicle number, similar vesicle diameter, similar average vesicle distance from the T-bar centroid.

      (Harris et al., 2015)

      Blood cells from mutant animals can phagocytose bacteria.

      (Choe et al., 2002)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      PGRP-LC2
      (Harris et al., 2018, Harris et al., 2015)
      PGRP2
      (Harris et al., 2018, Harris et al., 2015)
      ird72
      (Choe et al., 2002)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)