FlyBase Allele Report: Dmel\Ilp2[hs.PR]

General Information

Symbol

Dmel\Ilp2^hs.PR

Species

D. melanogaster

Name

heat shock construct of Rulifson

FlyBase ID

FBal0137484

Feature type

allele

Associated gene

Dmel\Ilp2

Associated Insertion(s)

Carried in Construct

P{hs-Ilp2.R}

Also Known As

hs-dilp2, hs-Ilp2

Key Links

Transgenic product class

cDNA

(Rulifson et al., 2002)

wild_type

(Rulifson et al., 2002)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

cDNA

(Rulifson et al., 2002)

wild_type

(Rulifson et al., 2002)

Mutagen

in vitro construct

(Rulifson et al., 2002, Rulifson et al., 2002)

Progenitor genotype

Carried in construct

P{hs-Ilp2.R}

Cytology

Description

A heat shock promoter drives expression of Ilp2 EST GH11579.

(Rulifson et al., 2002)

Allele components

Component

Use(s)

Regulatory region(s)

Hsp70

Encoded product / tool

Ilp2

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

increased body size | heat sensitive

(Walker et al., 2013)

Phenotype Manifest In

Detailed Description

Statement

Reference

Expression of Ilp2^hs.PR using heat shock results in an increase in pupal length compared to wild type.

(Walker et al., 2013)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhanced by

Statement

Reference

Ilp2^hs.PR has increased body size | heat sensitive phenotype, non-enhanceable by Nf1^E2

(Walker et al., 2013)

NOT suppressed by

Statement

Reference

Ilp2^hs.PR has increased body size | heat sensitive phenotype, non-suppressible by Nf1^E2

(Walker et al., 2013)

Suppressor of

Statement

Reference

Ilp2^hs.PR/Ilp2^hs.PR is a suppressor | partially of abnormal developmental rate | recessive phenotype of pHCl-2^pTV-Cherry

(Redhai et al., 2020)

Ilp2^hs.PR is a suppressor of decreased body size phenotype of Scer\GAL4^Ilp2.PR, rpr^UAS.C

(Rulifson et al., 2002)

Ilp2^hs.PR is a suppressor | heat sensitive of decreased cell number phenotype of Scer\GAL4^Ilp2.PR, rpr^UAS.C

(Rulifson et al., 2002)

Ilp2^hs.PR is a suppressor | heat sensitive of decreased cell size phenotype of Scer\GAL4^Ilp2.PR, rpr^UAS.C

(Rulifson et al., 2002)

Ilp2^hs.PR is a suppressor | heat sensitive of abnormal developmental rate phenotype of Scer\GAL4^Ilp2.PR, rpr^UAS.C

(Rulifson et al., 2002)

NOT Suppressor of

Statement

Reference

Ilp2^hs.PR/Ilp2^hs.PR is a non-suppressor of decreased rate of feeding behavior | larval stage phenotype of pHCl-2^pTV-Cherry

(Redhai et al., 2020)

Phenotype Manifest In

Suppressor of

Statement

Reference

Ilp2^hs.PR is a suppressor | heat sensitive of wing phenotype of Scer\GAL4^Ilp2.PR, rpr^UAS.C

(Rulifson et al., 2002)

NOT Suppressor of

Statement

Reference

Ilp2^hs.PR is a non-suppressor of follicle cell phenotype of Scer\GAL4^Ilp2.PR, rpr^UAS.C

(LaFever and Drummond-Barbosa, 2005)

Additional Comments

Genetic Interactions

Statement

Reference

Nf1^E2 has no effect on in the increased pupal length phenotype caused by expression of Ilp2^hs.PR using heat shock.

(Walker et al., 2013)

Females in which insulin-like peptide (ILP)-producing brain cells have been ablated (by expression of rpr^Scer\UAS.C under the control of Scer\GAL4^Ilp2.PR) and which also express Ilp2^hs.PR during larval development (to rescue developmental defects caused by the ablation of the ILP-producing brain cells) still show a reduced follicle cell proliferation rate in response to a protein-rich diet.

(LaFever and Drummond-Barbosa, 2005)

The size of larvae expressing rpr^Scer\UAS.C under the control of Scer\GAL4^Ilp2.PR at 120 hours of development is rescued to 88% of normal by expression of Ilp2^hs.PR. The wing growth defects are also rescued. The developmental time to reach wandering third instar and puparium formation is approximately 6 days in these rescued larvae, compared to 5 days in wild type.

(Rulifson et al., 2002)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

37472

w^*; P{hs-Ilp2.R}2/CyO, amos^Roi-1

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

IRP^hs.PR

Ilp2^hs.PR

Name Synonyms

heat shock construct of Rulifson

(Rulifson et al., 2002, Rulifson et al., 2002)

Secondary FlyBase IDs

References (6)

Report Sections

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