FlyBase Allele Report: Dmel\osk[fs(1)K10.3'UTR.UAS]

General Information

Symbol

Dmel\osk^{fs(1)K10.3'UTR.UAS}

Species

D. melanogaster

Name

FlyBase ID

FBal0141005

Feature type

allele

Associated gene

Dmel\osk

Associated Insertion(s)

Carried in Construct

P{UAS-osk.K10.3'UTR}

Also Known As

UASp-osk-K10, UAS-osk-K10 3'UTR

Key Links

Transgenic product class

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

Mutagen

in vitro construct

(Riechmann et al., 2002, Vanzo and Ephrussi, 2002)

Progenitor genotype

Carried in construct

P{UAS-osk.K10.3'UTR}

Cytology

Description

UAS regulatory sequences drive expression of osk in which the osk 3'UTR has been replaced with the fs(1)K10 3'UTR.

(Riechmann et al., 2002, Vanzo and Ephrussi, 2002)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

osk

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

embryonic head, with Scer\GAL4^{VP16.nanos.UTR}

(Zaessinger et al., 2006)

Detailed Description

Statement

Reference

Expression of osk^{fs(1)K10.3'UTR.Scer\UAS} under the control of Scer\GAL4^{nos.UTR.T:Hsim\VP16} results in bicaudal embryos (51%), embryos with strong anterior defects or no anterior structures (25%), and embryos with weak anterior defects (13%).

(Zaessinger et al., 2006)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Suppressor of

Statement

Reference

osk^{fs(1)K10.3'UTR.UAS}/Scer\GAL4^{VP16.nanos.UTR} is a non-suppressor of increased occurrence of cell division | oogenesis phenotype of Scer\GAL4^{VP16.nanos.UTR}, bru1^UASp.cFa

(Filardo and Ephrussi, 2003)

osk^{fs(1)K10.3'UTR.UAS}/Scer\GAL4^{VP16.nanos.UTR} is a non-suppressor of decreased occurrence of cell division | oogenesis phenotype of Scer\GAL4^{VP16.nanos.UTR}, bru1^UASp.cFa

(Filardo and Ephrussi, 2003)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

osk^{fs(1)K10.3'UTR.Scer\UAS} does not suppress the germ cell replication defects seen in Scer\GAL4^{nos.UTR.T:Hsim\VP16}; aret^{Scer\UAS.P\T.cFa} ovarioles.

(Filardo and Ephrussi, 2003)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to rescue

osk^{fs(1)K10.3'UTR.UAS}, Scer\GAL4^VP16.otu, Scer\GAL4^{VP16.nanos.UTR} fails to rescue osk^A87/Df(3R)p-XT103

(Jenny et al., 2006)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

RNA transcribed from this transgene is unable to associate with stau protein.

(Jenny et al., 2006)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

osk^{fs(1)K10.3'UTR.Scer\UAS}

osk^{fs(1)K10.3'UTR.UAS}

Name Synonyms

Secondary FlyBase IDs

References (8)

Report Sections

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