FlyBase Allele Report: Dmel\wun[EMS23]

General Information

Symbol

Dmel\wun^EMS23

Species

D. melanogaster

Name

FlyBase ID

FBal0143106

Feature type

allele

Associated gene

Dmel\wun

Associated Insertion(s)

Carried in Construct

Also Known As

wun²³

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Kozopas, 2003.3)

Progenitor genotype

Cytology

Description

Nucleotide substitution: G?A.

(Renault, 2013.10.7)

Amino acid replacement: W246term.

(Renault, 2013.10.7)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

2R:9,402,460..9,402,460 [-]

Nucleotide change:

G9402460A

Reported nucleotide change:

G?A

Amino acid change:

W246term | wun-PA; W325term | wun-PB; W325term | wun-PC

Reported amino acid change:

W246term

Comment:

TGG to TGA nonsense mutation in codon W246.

Comment:

TGG to TGA nucleotide change resulting in a W246 nonsense mutation.

(Renault, 2013.10.7, Renault et al., 2004)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

decreased fecundity | maternal effect (with wun^EMS9)

(Mukherjee et al., 2023)

female sterile (with wun^EMS9)

(Mukherjee et al., 2023)

lethal | recessive

(Kozopas, 2003.3)

lethal - all die during embryonic stage | maternal effect (with wun^EMS9)

(Mukherjee et al., 2023)

visible | embryonic stage | maternal effect (with wun^EMS9)

(Mukherjee et al., 2023)

Phenotype Manifest In

dorsal appendage | embryonic stage | maternal effect (with wun^EMS9)

(Mukherjee et al., 2023)

endochorion | maternal effect (with wun^EMS9)

(Mukherjee et al., 2023)

exochorion | maternal effect (with wun^EMS9)

(Mukherjee et al., 2023)

vitelline membrane | maternal effect (with wun^EMS9)

(Mukherjee et al., 2023)

Detailed Description

Statement

Reference

Embryos derived from wun^EMS23/wun^EP2650ex34 females mated to wild-type males have wild-type germ cell numbers at late stages.

(Renault et al., 2004)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT suppressed by

Statement

Reference

wun^EMS9/wun^EMS23 has lethal - all die during embryonic stage | maternal effect phenotype, non-suppressible by Scer\GAL4^c563/Lpin^UAS.cUa

(Mukherjee et al., 2023)

wun^EMS9/wun^EMS23 has female sterile phenotype, non-suppressible by Scer\GAL4^c563/Lpin^UAS.cUa

(Mukherjee et al., 2023)

wun^EMS9/wun^EMS23 has decreased fecundity | maternal effect phenotype, non-suppressible by Scer\GAL4^c563/Lpin^UAS.cUa

(Mukherjee et al., 2023)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

wun^k10201

(Kozopas, 2003.3)

wun^k15909

(Kozopas, 2003.3)

wun^k09507

(Kozopas, 2003.3)

Partially rescued by

wun^EMS9/wun^EMS23 is partially rescued by Scer\GAL4^T155/wun^UAS.cZa

(Mukherjee et al., 2023)

Not rescued by

wun^EMS9/wun^EMS23 is not rescued by Scer\GAL4^c563/wun^UAS.cZa

(Mukherjee et al., 2023)

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

6951

wun^EMS23/CyO; ry⁵⁰⁶

Notes on Origin

Discoverer

Arose in: screen described in FBrf0102352.

(Kozopas, 2003.3)

Comments

Fails to complement: wun^k16806.

(Kozopas, 2003.3)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

wun²³

(Mukherjee et al., 2023, Ile et al., 2012)

wun^EMS23

(Renault, 2013.10.7)

wun[EMS23]

(Renault et al., 2004)

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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