FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\savshrp-4
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General Information
Symbol
Dmel\savshrp-4
Species
D. melanogaster
Name
FlyBase ID
FBal0143233
Feature type
allele
Associated gene
Dmel\sav
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Kango-Singh et al., 2002)
Mutagen
ethyl methanesulfonate
(Kango-Singh et al., 2002)
Progenitor genotype
Cytology
Description

Amino acid replacement: R255term.

(Kango-Singh et al., 2002)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:23,060,421..23,060,421 [-]
Nucleotide change:

C23060421T

Amino acid change:

R255term | sav-PA; R255term | sav-PB

Reported amino acid change:

R255term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Kango-Singh et al., 2002)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Mosaic animals in which the head is homozygous for savshrp-4 (made using the "eyFLP" technique) have enlarged heads, but patterning of the head cuticle is unaffected. Homozygous clones in the eye disc result in a dramatic increase in the number of interommatidial cells compared to wild type. These extra interommatidial cells differentiate into pigment cells. The number of cells in clones in the third larval instar wing disc is generally larger than the number of cells in their wild-type twin clones. The population of cells in the mutant clones have the same distribution of cell cycle phases as the wild-type cells and they are normal in size.

      (Kango-Singh et al., 2002)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      savshrp-4
      shrp4
      (Kango-Singh et al., 2002)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)