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General Information
Symbol
Dmel\AP-2αSH0460
Species
D. melanogaster
Name
FlyBase ID
FBal0144009
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
ada5
Key Links
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Insertion components
P{lacW}AP-2αSH0460
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Some metaphase furrows in embryos derived from AP-2αSH0460 germline clones are lost in patches across each embryo, and those furrows present surround many DNA elements, unlike in controls. These two phenotypes overlap: regions of embryos lacking actin rings also lack plasma membrane furrows.

α-AdaptinSH0460 mutant larval brains contain supernumerary neuroblasts but few differentiated neurons in the central brain.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
NOT suppressed by
Statement
Reference
Phenotype Manifest In
Suppressed by
NOT suppressed by
Additional Comments
Genetic Interactions
Statement
Reference

Expression of NVDRC.cUa under the control of Scer\GAL4insc-Mz1407 completely suppresses the supernumerary neuroblast phenotype in α-AdaptinSH0460 mutant larval brains.

Overexpression of numbScer\UAS.T:Avic\GFP under the control of Scer\GAL4insc-Mz1407 fails to suppress the supernumerary neuroblast phenotype in α-AdaptinSH0460 mutant larval brains.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments

Neuroblast-specific expression of α-AdaptinΔNTΔEar.Scer\UAS.T:Avic\GFP via Scer\GAL4insc-Mz1407 fails to rescue the neuroblast overproliferation phenotype of α-AdaptinSH0460 and α-Adaptin06694 mutants.

Neuroblast-specific expression of α-AdaptinN2.Scer\UAS.T:Avic\GFP via Scer\GAL4insc-Mz1407 fails to rescue the neuroblast overproliferation phenotype of α-AdaptinSH0460 mutants.

Neuroblast-specific expression of α-AdaptinTrunk.Scer\UAS.T:Avic\GFP via Scer\GAL4insc-Mz1407 completely rescues the neuroblast overproliferation phenotype of α-AdaptinSH0460 mutants.

Neuroblast-specific expression of α-AdaptinΔEar.Scer\UAS.T:Avic\GFP via Scer\GAL4insc-Mz1407 completely rescues the neuroblast overproliferation phenotype of α-AdaptinSH0460 mutants.

Neuroblast-specific expression of α-AdaptinΔEar5.Scer\UAS.T:Avic\GFP via Scer\GAL4insc-Mz1407 completely rescues the neuroblast overproliferation phenotype of α-AdaptinSH0460 mutants.

Neuroblast-specific expression of α-AdaptinScer\UAS.T:Avic\GFP via Scer\GAL4insc-Mz1407 completely rescues the brain tumor phenotype of α-AdaptinSH0460.

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (4)
Reported As
Symbol Synonym
AP-2αSH0460
l(2)SH0460SH0460
α-AdaptinSH0460
Name Synonyms
Secondary FlyBase IDs
    References (3)