FlyBase Allele Report: Dmel\grim[L89A.UAS]

General Information

Symbol

Dmel\grim^L89A.UAS

Species

D. melanogaster

Name

FlyBase ID

FBal0144257

Feature type

allele

Associated gene

Dmel\grim

Associated Insertion(s)

Carried in Construct

P{UAS-grim.L89A}

Key Links

Transgenic product class

missense_variant

(Claveria et al., 2002)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

missense_variant

(Claveria et al., 2002)

Mutagen

in vitro construct

(Claveria et al., 2002)

Progenitor genotype

Carried in construct

P{UAS-grim.L89A}

Cytology

Description

UASt regulatory sequences drive expression of a mutant form of grim (carries the amino acid replacement L89A).

(Claveria et al., 2002)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

grim

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal, with Scer\GAL4^Bx-MS1096

(Claveria et al., 2002)

lethal, with Scer\GAL4^GMR.PF

(Claveria et al., 2002)

Phenotype Manifest In

eye, with Scer\GAL4^GMR.PF

(Claveria et al., 2002)

macrochaeta, with Scer\GAL4^Bx-MS1096

(Claveria et al., 2002)

mesonotum, with Scer\GAL4^Bx-MS1096

(Claveria et al., 2002)

microchaeta, with Scer\GAL4^Bx-MS1096

(Claveria et al., 2002)

wing, with Scer\GAL4^Bx-MS1096

(Claveria et al., 2002)

Detailed Description

Statement

Reference

When grim^{L89A.Scer\UAS} is driven by Scer\GAL4^Bx-MS1096 a notum and wing reduction phenotype is seen. When grim^{L89A.Scer\UAS} is driven by Scer\GAL4^GMR.PF, about 20% of animals survive. When grim^{L89A.Scer\UAS} is driven by Scer\GAL4^Bx-MS1096, almost no animals survive. grim^{L89E.Scer\UAS} when driven by Scer\GAL4^GMR.PF causes an eye reduction phenotype.

(Claveria et al., 2002)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

grim^{L89A.Scer\UAS}

grim^L89A.UAS

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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