FlyBase Allele Report: Dmel\mir-ban[L1170a]

General Information

Symbol

Dmel\mir-ban^L1170a

Species

D. melanogaster

Name

FlyBase ID

FBal0144427

Feature type

allele

Associated gene

Dmel\mir-ban

Associated Insertion(s)

P{lacW}mir-ban^L1170a

Carried in Construct

Also Known As

ban-lacZ, bantam-lacZ, ban^L1170, P{lacW}banL1170a

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Brennecke et al., 2003, Hipfner et al., 2002)

Progenitor genotype

Associated Insertion(s)

P{lacW}mir-ban^L1170a

Cytology

Description

Allele components

Component

Use(s)

Inserted element

P{lacW}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

3L:639,743..639,743 [-]

(Bilak et al., 2014, Shcherbata et al., 2007, Brennecke et al., 2003, Hipfner et al., 2002)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

decreased body size (with Df(3L)mir-ban^Δ1)

(Hipfner et al., 2002)

decreased cell number (with Df(3L)mir-ban^Δ1)

(Hipfner et al., 2002)

decreased cell number | adult stage | somatic clone (with Df(3L)mir-ban^Δ1)

(Shcherbata et al., 2007)

decreased cell number | adult stage | somatic clone (with mir-ban^EP3622)

(Shcherbata et al., 2007)

decreased cell number | larval stage | somatic clone (with Df(3L)mir-ban^Δ1)

(Shcherbata et al., 2007)

decreased cell number | larval stage | somatic clone (with mir-ban^EP3622)

(Shcherbata et al., 2007)

decreased cell number | pupal stage | somatic clone (with Df(3L)mir-ban^Δ1)

(Shcherbata et al., 2007)

decreased cell number | pupal stage | somatic clone (with mir-ban^EP3622)

(Shcherbata et al., 2007)

female sterile (with Df(3L)mir-ban^Δ1)

(Hipfner et al., 2002)

increased cell death (with mir-ban^EP3622)

(Jaklevic et al., 2008)

viable (with Df(3L)mir-ban^Δ1)

(Hipfner et al., 2002)

Phenotype Manifest In

Detailed Description

Statement

Reference

ban^L1170a homozygotes or ban^L1170a/Df(3L)ban^Δ1 hemizygotes survive to adulthood and show wild-type levels of apoptosis. Imaginal discs in ban^L1170a homo- and hemizygotes or ban^EP3622/ban^L1170a transheterozygotes show significantly higher levels of AO staining than wild-type, indicating that these mutants undergo IR-induced apoptosis more readily than wild-type.

(Jaklevic et al., 2008)

ban^L1170a/ban^EP3622 mutant germline stem cells (GSCs) show maintenance and cell division defects when clones are generated during adult stages. When ban^L1170a/ban^EP3622 clones are generated in larval and pupal stages the GSC loss is less severe.

ban^L1170a/Df(3L)ban^Δ1 mutant germline stem cells (GSCs) show maintenance and cell division defects when clones are generated during adult stages. When ban^L1170a/Df(3L)ban^Δ1 clones are generated in larval and pupal stages the GSC loss is less severe.

(Shcherbata et al., 2007)

The body mass of ban^L1170a/Df(3L)ban^Δ1 adults is only 85% of that of control flies. The wing blade area of ban^L1170a/Df(3L)ban^Δ1 flies is only 87% of that of controls. This decrease is entirely due to a decrease in the number of cells, and is not due to a decrease in cell size.

(Hipfner et al., 2002)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

mir-ban^L1170a has radiation sensitive phenotype, enhanceable by Df(3L)Exel6115/+

(Bilak et al., 2014)

mir-ban^L1170a has radiation sensitive phenotype, enhanceable by Tie^Exel9028/Tie[+]

(Bilak et al., 2014)

mir-ban^L1170a has radiation sensitive phenotype, enhanceable by Tie^e03394/Tie[+]

(Bilak et al., 2014)

mir-ban^L1170a has radiation sensitive phenotype, enhanceable by Tie[+]/Tie^C098

(Bilak et al., 2014)

mir-ban^L1170a has radiation sensitive phenotype, enhanceable by Tie^e02680/Tie[+]

(Bilak et al., 2014)

Suppressed by

Statement

Reference

mir-ban^L1170a has radiation sensitive phenotype, suppressible by Df(3L)Exel6086/+

(Bilak et al., 2014)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

EP3219^EP3219 combined with ban^L1170a has little or no effect on growth.

(Hipfner et al., 2002)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

10154

y¹ w¹¹¹⁸; P{lacW}mir-ban^L1170a lncRNA:CR43334^L1170a, l(3)L1170b^L1170b/TM3, Ser¹

Kyoto

111004

y^d2 w¹¹¹⁸ P{ey-FLP.N}2 P{5xglBS-lacZ.38-1}TPN1; P{lacW}mir-ban^L1170a P{neoFRT}80B/TM6B, P{Car20y}TPN1, Tb¹

Notes on Origin

Discoverer

Separable from: l(3)L1170b^L1170b. The P{lacW}ban^L1170a insertion (which causes a size reduction phenotype) is separable from the lethality of the "l(3)L1170" chromosome (which is caused by l(3)L1170b^L1170b).

(Hipfner et al., 2002)

Comments

Precise excision of the P{lacW}ban^L1170a element completely reverts the size reduction and female sterility phenotypes.

(Hipfner et al., 2002)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

ban¹¹⁷⁰

(Bilak et al., 2014)

ban^L1170

(Jaklevic et al., 2008, Shcherbata et al., 2007, Hipfner et al., 2002)

ban^L1170a

(Azuma et al., 2018)

mir-ban^L1170a

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections

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