FlyBase Allele Report: Dmel\amon[Q178st]

General Information

Symbol

Dmel\amon^Q178st

Species

D. melanogaster

Name

FlyBase ID

FBal0144470

Feature type

allele

Associated gene

Dmel\amon

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Rayburn et al., 2003)

Progenitor genotype

Cytology

Description

Amino acid replacement: Q178term.

(Rayburn et al., 2003)

Nucleotide substitution: C?T.

(Rayburn et al., 2003)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3R:26,702,662..26,702,662 [-]

Nucleotide change:

C26702662T

Reported nucleotide change:

C?T

Amino acid change:

Q178term | amon-PA

Reported amino acid change:

Q178term

(Rayburn et al., 2003)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | embryonic stage (with Df(3R)Tl-X)

(Rayburn et al., 2003)

lethal | larval stage (with Df(3R)Tl-X)

(Rayburn et al., 2003)

lethal | recessive

(Rayburn et al., 2003)

Phenotype Manifest In

larval head

(Rayburn et al., 2009)

leg

(Rayburn et al., 2009)

leg disc

(Rayburn et al., 2009)

mesothoracic leg disc

(Rayburn et al., 2009)

metathoracic leg disc

(Rayburn et al., 2009)

prothoracic leg disc

(Rayburn et al., 2009)

wing

(Rayburn et al., 2009)

wing disc

(Rayburn et al., 2009)

Detailed Description

Statement

Reference

The predominant phenotype of arrested amon^Q178st animals is a failure to evert the head coupled with a failure to extend the legs and wings (33%). Interestingly, the failures in head eversion and leg and wing extension do not preclude further development of these structures as evidenced by tanning and bristle formation, nor did they prevent the differentiation and pigmentation of the eye.

(Rayburn et al., 2009)

amon^Q178st/Df(3R)Tl-X animals that arrest during larval development usually have duplicated pairs of larval mouth hooks, which are identifiable by morphology as first and second instar larval mouth hooks.

(Rayburn et al., 2003)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Df(3R)Tl-X/amon^Q178st is rescued by amon^hs.PS

(Rayburn et al., 2009)

Partially rescued by

Df(3R)Tl-X/amon^Q178st is partially rescued by amon^hs.PS

(Rhea et al., 2010)

Comments

Expression of amon^hs.PS using a single heat shock during the first larval instar is sufficient to rescue amon^Q178st/Df(3R)Tl-X larvae to the second larval instar stage, but not to the third larval instar stage.

(Rhea et al., 2010)

Continuous daily expression of amon^hs.PS starting at 36 hours after egg laying (AEL) rescues amon^Q178st/Df(3R)Tl-X mutant hemizygotes, to adulthood. In contrast, removal of heat-shock treatment at the late third instar stage (108 hours AEL) results in a failure to eclose.

(Rayburn et al., 2009)

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

29012

y¹ w^*; amon^Q178st e^*/TM3, Sb¹ Ser¹, y⁺

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

amon^Q178ST

(Rhea et al., 2010)

amon^Q178st

(Kellermeyer et al., 2020, Rhea et al., 2010, Rayburn et al., 2009)

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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