FB2026_02 , released June 18, 2026
Allele: Dmel\amonhs.PS
Open Close
General Information
Symbol
Dmel\amonhs.PS
Species
D. melanogaster
Name
heat shock construct of Siekhaus
FlyBase ID
FBal0098783
Feature type
allele
Associated gene
Dmel\amon
Associated Insertion(s)
Carried in Construct
P{hs-amon.S}
Also Known As
hs-amon
Key Links
Transgenic product class
cDNA
(Siekhaus and Fuller, 1999)
wild_type
(Siekhaus and Fuller, 1999)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Siekhaus and Fuller, 1999)
wild_type
(Siekhaus and Fuller, 1999)
Mutagen
in vitro construct
(Siekhaus and Fuller, 1999)
Progenitor genotype
Carried in construct
P{hs-amon.S}
Cytology
Description

A wild-type amon cDNA is expressed under the control of a heat shock promoter.

(Siekhaus and Fuller, 1999)
Allele components
Component
Use(s)
Regulatory region(s)
Hsp70
Encoded product / tool
amon
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      amonC241Y/Df(3R)Tl-X third instar larvae (which have been rescued to this stage by expression of amonhs.PS using a 35 minute heat shock every 24 hours until the third larval instar stage) show a normal radius of movement 1 day after the last heat shock (ALH), but at 2 days ALH, the mutant larvae have a reduced movement radius compared to the control larvae (which have entered the wandering stage). At 3 days ALH, the mutant larvae remain in the food, while control larvae have started to pupariate.

      (Wegener et al., 2011)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      amonhs.PS rescues Df(3R)Tl-X/amonC241Y

      (Rayburn et al., 2009)

      amonhs.PS rescues Df(3R)Tl-X/amonQ178st

      (Rayburn et al., 2009)
      Partially rescues

      amonhs.PS partially rescues Df(3R)Tl-X/amonQ178st

      (Rhea et al., 2010)

      amonhs.PS partially rescues Df(3R)Tl-X/amonC241Y

      (Rayburn et al., 2003)

      amonhs.PS partially rescues Df(3R)Tl-X/Df(3R)ro80b

      (Siekhaus and Fuller, 1999)
      Comments

      Expression of amonhs.PS using a single heat shock during the first larval instar is sufficient to rescue amonQ178st/Df(3R)Tl-X larvae to the second larval instar stage, but not to the third larval instar stage.

      (Rhea et al., 2010)

      Continuous daily expression of amonhs.PS starting at 36 hours after egg laying (AEL) rescues amonC241Y/Df(3R)Tl-X and amonQ178st/Df(3R)Tl-X mutant hemizygotes, to adulthood. In contrast, removal of heat-shock treatment at the late third instar stage (108 hours AEL) results in a failure to eclose.

      Approximately 27% of amonC241Y mutants do not complete abdominal differentiation. The undifferentiated abdomens resemble those of stage P5, which are transparent and lack segmentation and bristles. The failure in abdominal differentiation does not however, prevent the thoracic segment from acquiring pigment and bristles, indicating that these two body segments are governed by distinct developmental controls.

      (Rayburn et al., 2009)

      Rescues the hatching behavioural defects of Df(3R)Tl-X/Df(3R)ro80b animals in some cases.

      (Siekhaus and Fuller, 1999)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      amonhs.PS
      Name Synonyms
      heat shock construct of Siekhaus
      (Siekhaus and Fuller, 1999)
      Secondary FlyBase IDs
        References (5)