FlyBase Allele Report: Dmel\Syb[144]

General Information

Symbol

Dmel\Syb¹⁴⁴

Species

D. melanogaster

Name

FlyBase ID

FBal0144501

Feature type

allele

Associated gene

Dmel\Syb

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

loss of function allele

Mutagen

P-element activity

Nature of the Allele

Allele class

loss of function allele

(Bhattacharya et al., 2002)

Mutagen

P-element activity

(Bhattacharya et al., 2002)

Progenitor genotype

P{lacW}Syb^k07705

(Bhattacharya et al., 2002)

Cytology

Description

Imprecise excision of the P{lacW} element, resulting in a deletion which removes all of the Syb open reading frame apart from 16 N-terminal amino acids encoded by exon 2 and 25 C-terminal amino acids of Syb-a encoded by exon 5.

(Bhattacharya et al., 2002)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

cell lethal | recessive | somatic clone

(Bhattacharya et al., 2002)

Phenotype Manifest In

eye | somatic clone

(Bhattacharya et al., 2002)

larval tracheal system | embryonic stage

(Tsarouhas et al., 2023)

ommatidium | somatic clone

(Bhattacharya et al., 2002)

tracheal lumen | embryonic stage

(Tsarouhas et al., 2023)

Detailed Description

Statement

Reference

Mosaic animals in which the eyes are made homozygous for Syb¹⁴⁴ fail to develop eyes and all or nearly all of the ommatidia are missing.

(Bhattacharya et al., 2002)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Syb¹⁴⁴ has cell lethal | recessive | somatic clone phenotype, suppressible by Rat\cellubrevin^UAS.cBa/Scer\GAL4^ey.PH

(Bhattacharya et al., 2002)

Phenotype Manifest In

Suppressed by

Statement

Reference

Syb¹⁴⁴ has eye | somatic clone phenotype, suppressible by Rat\cellubrevin^UAS.cBa/Scer\GAL4^ey.PH

(Bhattacharya et al., 2002)

Additional Comments

Genetic Interactions

Statement

Reference

The failure of eye development seen in mosaic flies in which the eyes are homozygous for Syb¹⁴⁴ is rescued by expression of Rat\cellubrevin^Scer\UAS.cBa under the control of Scer\GAL4^ey.PH.

(Bhattacharya et al., 2002)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Syb¹⁴⁴

syb¹⁴⁴

(Tsarouhas et al., 2023, Yamazaki et al., 2016, Bhattacharya et al., 2002)

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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