FlyBase Allele Report: Dmel\Sod2[+t9]

General Information

Symbol

Dmel\Sod2^+t9

Species

D. melanogaster

Name

FlyBase ID

FBal0144562

Feature type

allele

Associated gene

Dmel\Sod2

Associated Insertion(s)

Carried in Construct

P{Sod2.9}

Key Links

Transgenic product class

genomic_DNA

(Mockett et al., 1999)

wild_type

(Mockett et al., 1999)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

genomic_DNA

(Mockett et al., 1999)

wild_type

(Mockett et al., 1999)

Mutagen

in vitro construct

(Mockett et al., 1999)

Progenitor genotype

Carried in construct

P{Sod2.9}

Cytology

Description

Included within 9kb genomic SalI fragment that encompasses the Sod2 transcription unit with almost 7kb upstream sequence and 1.3kb downstream sequence.

(Mockett et al., 1999)

Allele components

Component

Use(s)

Regulatory region(s)

Sod2

Encoded product / tool

Sod2

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

short lived

(Mockett et al., 1999)

Phenotype Manifest In

Detailed Description

Statement

Reference

Longevity of flies carrying P{Sod2.9} is decreased by a mean of 4-5% relative to controls. Lines show no compensatory changes in metabolic rate, physical activity, or levels of other antioxidants. There was no change in the rate of mitochondrial hydrogen peroxide release, protein oxidative damage or resistance to 100% oxygen or starvation conditions. Lines did show a marginally increased resistance to moderate heat stress.

(Mockett et al., 1999)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Sod2^+t9/Cat^{Tag:Mito(Oat)} is a suppressor of short lived phenotype of Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155

(Besson et al., 2010)

NOT Suppressor of

Statement

Reference

Sod2^+t9/Cat^{Tag:Mito(Oat)} is a non-suppressor of short lived phenotype of Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^Eaat1.PR

(Besson et al., 2010)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Co-expression of Cat^tOa, Sod^+t2.4 and Sod2^+t9 does not result in an increase in life span.

(Orr et al., 2003)

Xenogenetic Interactions

Statement

Reference

The presence of Sod2^+t9 and Cat^T:mito1 does not prevent the early death of adult flies expressing Hsap\HTT^{Q93.ex1p.Scer\UAS} under the control of Scer\GAL4^Eaat1.PR, but does improve the survival of flies expressing Hsap\HTT^{Q93.ex1p.Scer\UAS} under the control of Scer\GAL4^elav-C155.

(Besson et al., 2010)

Complementation and Rescue Data

Rescues

Sod2^+t9 rescues Sod2^bwd

(Celotto et al., 2012)

Sod2^+t9 rescues Sod2ⁿ²⁸³/Df(2R)Exel6064

(Belton et al., 2006)

Sod2^+t9 rescues Sod2¹¹/Df(2R)Exel6064

(Belton et al., 2006)

Sod2^+t9 rescues Df(2R)Sod2-332

(Belton et al., 2006)

Sod2^+t9 rescues Sod2¹¹