FlyBase Allele Report: Dmel\Cat[Tag:Mito(Oat)]

General Information

Symbol

Dmel\Cat^{Tag:Mito(Oat)}

Species

D. melanogaster

Name

FlyBase ID

FBal0150934

Feature type

allele

Associated gene

Dmel\Cat

Associated Insertion(s)

Carried in Construct

P{OAT-Cat}

Also Known As

mitoCatalase

Key Links

Transgenic product class

genomic_DNA

(Kwong et al., 2000)

wild_type

(Kwong et al., 2000)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

genomic_DNA

(Kwong et al., 2000)

wild_type

(Kwong et al., 2000)

Mutagen

in vitro construct

(Kwong et al., 2000)

Progenitor genotype

Carried in construct

P{OAT-Cat}

Cytology

Description

Contains a genomic fragment containing the Cat promoter and entire Cat exon and intron sequences, in which the Tag:Mito(Oat) mitochondrial targeting tag has been fused to the beginning of the Cat coding region.

(Kwong et al., 2000)

Allele components

Component

Use(s)

Regulatory region(s)

Cat

Encoded product / tool

Cat

Tagged with

Tag:Mito(Oat)

mitochondrial protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Cat^{Tag:Mito(Oat)}, Scer\GAL4^elav-C155 is a suppressor | partially of abnormal locomotor behavior | adult stage phenotype of Scer\GAL4^elav-C155, fh^UAS.cLa

(Edenharter et al., 2017)

Cat^{Tag:Mito(Oat)} is a suppressor of short lived phenotype of Scer\GAL4^{neur-GAL4-A101}, fh^UAS.cLa

(Navarro et al., 2011)

Cat^{Tag:Mito(Oat)} is a suppressor of abnormal locomotor behavior phenotype of Scer\GAL4^repo, fh^UAS.cLa

(Navarro et al., 2011)

Cat^{Tag:Mito(Oat)} is a suppressor of short lived phenotype of Hsap\FXN^UAS.cNa, Scer\GAL4^{neur-GAL4-A101}

(Navarro et al., 2011)

Cat^{Tag:Mito(Oat)} is a suppressor of abnormal locomotor behavior phenotype of Hsap\FXN^UAS.cNa, Scer\GAL4^repo

(Navarro et al., 2011)

Sod2^+t9/Cat^{Tag:Mito(Oat)} is a suppressor of short lived phenotype of Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155

(Besson et al., 2010)

Cat^{Tag:Mito(Oat)} is a suppressor | partially of abnormal immune response phenotype of Irc^RNAi.UAS, Scer\GAL4^da.PU

(Ha et al., 2005)

NOT Suppressor of

Statement

Reference

Cat^{Tag:Mito(Oat)} is a non-suppressor of short lived phenotype of Scer\GAL4^repo, fh^UAS.cLa

(Navarro et al., 2011)

Cat^{Tag:Mito(Oat)} is a non-suppressor of short lived phenotype of Hsap\FXN^UAS.cNa, Scer\GAL4^repo

(Navarro et al., 2011)

Sod2^+t9/Cat^{Tag:Mito(Oat)} is a non-suppressor of short lived phenotype of Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^Eaat1.PR

(Besson et al., 2010)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Constitutive expression of Cat^T:Mito-oat significantly extends the lifespan of flies expressing fh^Scer\UAS.cLa under the control of Scer\GAL4^{neur-GAL4-A101}.

Constitutive expression of Cat^T:Mito-oat fails to extend the lifespan of flies expressing fh^Scer\UAS.cLa under the control of Scer\GAL4^repo.

Constitutive expression of Cat^T:Mito-oat ameliorates the climbing deficiency that is induced by expression of fh^Scer\UAS.cLa in glial cells under the control of Scer\GAL4^repo.

(Navarro et al., 2011)

The reduced survival rate after natural infection with "Ecc-15" (P.carotovorum.carotovorum) that is seen in flies expressing Irc^{dsRNA.Scer\UAS} under the control of Scer\GAL4^da.G32 is partially rescued by co-expression of Cat^T:mito1.

(Ha et al., 2005)

Xenogenetic Interactions

Statement

Reference

Constitutive expression of Cat^T:Mito-oat significantly extends the lifespan of flies expressing Hsap\FXN^Scer\UAS.cNa under the control of Scer\GAL4^{neur-GAL4-A101}.

Constitutive expression of Cat^T:Mito-oat fails to extend the lifespan of flies expressing Hsap\FXN^Scer\UAS.cNa under the control of Scer\GAL4^repo.

Constitutive expression of Cat^T:Mito-oat ameliorates the climbing deficiency that is induced by expression of Hsap\FXN^Scer\UAS.cNa in glial cells under the control of Scer\GAL4^repo.

(Navarro et al., 2011)

The presence of Sod2^+t9 and Cat^T:mito1 does not prevent the early death of adult flies expressing Hsap\HTT^{Q93.ex1p.Scer\UAS} under the control of Scer\GAL4^Eaat1.PR, but does improve the survival of flies expressing Hsap\HTT^{Q93.ex1p.Scer\UAS} under the control of Scer\GAL4^elav-C155.

(Besson et al., 2010)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Cat^T:Mito-oat

Cat^T:mito1

Cat^{Tag:Mito(Oat)}

Name Synonyms

Secondary FlyBase IDs

References (7)

Report Sections

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