FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\cpoEG1
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General Information
Symbol
Dmel\cpoEG1
Species
D. melanogaster
Name
FlyBase ID
FBal0144991
Feature type
allele
Associated gene
Dmel\cpo
Associated Insertion(s)
P{lacZ}cpoEG1
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
Delta2-3 transposase
(Zhang et al., 2002)
Progenitor genotype
Associated Insertion(s)
P{lacZ}cpoEG1
Cytology
Description

P{lacZ} insertion in an intron of cpo, 38bp upstream of the transcription start site (insertion site is between nucleotides 12297 and 12298 of scaffold AE003720, release 3).

(Glasscock and Tanouye, 2005)
Allele components
Component
Use(s)
Inserted element
P{lacZ}
Encoded product / tool
lacZ
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Heterozygotes show no paralysis following mechanical stimulation. cpoEG1/cpo1 and cpoEG1/cpo2 flies have behavioural abnormalities in phototaxis, geotaxis, flight and recovery from ether. The flies are sluggish and show defects in mating vigour. 32% of cpoEG1/cpo1 flies show bang sensitive paralysis. cpoEG1/cpov3 flies do not show bang sensitive paralysis. cpoEG1/cpo1 and cpoEG1/cpo2 flies are more sensitive to seizures induced by a high frequency stimulus than wild-type flies; the mean seizure threshold is reduced compared to wild-type flies, to 11.1 +/- 3.7 V and 13.3 +/- 4.8 V respectively. The recovery period following seizure for cpoEG1/cpo1 and cpoEG1/cpo2 flies is 83.2 +/- 23.8 seconds and 98.6 +/- 15.0 seconds respectively, which is considerably longer than the recovery period of wild-type flies. The firing threshold of the giant fiber in cpoEG1/+, cpoEG1/cpo1 and cpoEG1/cpo2 flies is not significantly different from wild type. cpoEG1 acts as a dominant enhancer of seizure susceptibility; the cpoEG1/+ sdaiso7.8/+ double heterozygote has a seizure threshold of 14.4 +/- 3.1 V. The giant fiber-tergotrochanteral muscle (GF-TTM) response is abnormal cpoEG1/cpo1 flies; the wild-type short latency response is replaced by a longer latency response that cannot follow even moderate frequencies of stimulation. However, in response to direct electrical stimulation, the cpoEG1/cpo1 TTM is similar to wild type in latency and following frequency. The giant fiber-dorsal longitudinal muscle (GF-DLM) response in cpoEG1/cpo1 animals is normal in latency but impaired in following frequency. In response to direct electrical stimulation, the cpoEG1/cpo1 DLM is similar to wild type in latency and following frequency. The giant fiber-tergotrochanteral muscle (GF-TTM) response is abnormal cpoEG1/cpo2 flies; the wild-type short latency response is replaced by a longer latency response that cannot follow even moderate frequencies of stimulation. The giant fiber-dorsal longitudinal muscle (GF-DLM) response in cpoEG1/cpo2 animals is normal in latency but impaired in following frequency.

      (Glasscock and Tanouye, 2005)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      cpo[+]/cpoEG1 is an enhancer of bang sensitive | dominant phenotype of jusiso7.8

      (Glasscock and Tanouye, 2005)

      cpo[+]/cpoEG1 is an enhancer of bang sensitive phenotype of jusiso7.8

      (Zhang et al., 2002)
      Other
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Selected as: a mutation that dominantly enhances the sdaiso7.8/+ bang sensitive phenotype.

      (Zhang et al., 2002)
      Comments
      Comments

      Precise excision of the insertion reverts the phenotype to wild type. Allelic series: cpoEG1 >= cpol2 > cpo1 >= cpo2.

      (Glasscock and Tanouye, 2005)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      E(sda)NN
      Line N
      (Zhang et al., 2002)
      cpoEG1
      Name Synonyms
      Secondary FlyBase IDs
        References (2)