FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Akap200k07118a
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General Information
Symbol
Dmel\Akap200k07118a
Species
D. melanogaster
Name
FlyBase ID
FBal0145228
Feature type
allele
Associated gene
Dmel\Akap200
Associated Insertion(s)
P{lacW}Akap200k07118a
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Jackson and Berg, 2002)
Progenitor genotype
Associated Insertion(s)
P{lacW}Akap200k07118a
Cytology
Description

P{lacW} insertion in the first intron.

(Jackson and Berg, 2002)
Allele components
Component
Use(s)
Inserted element
P{lacW}
Encoded product / tool
lacZ
Tagged with
Tag:NLS(P)
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygotes are recovered at slightly less than the expected frequency. Akap200k07118a/Df(2L)N22-14 animals show 81% viability. 19% of Akap200k07118a/Df(2L)N22-14 adults have at least one extra notal bristle. 11% of Akap200k07118a/Df(2L)N22-14 egg chambers have binucleate nurse cells with ring canal remnants and 3.2% have other defects. The diameters of the inner and outer rims of the ring canals are larger than normal.

      (Jackson and Berg, 2002)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhancer of
      Suppressor of
      Statement
      Reference

      Akap200k07118a/Akap200[+] is a suppressor of outer nurse cell ring canal rim phenotype of Src64BPI

      (Jackson and Berg, 2002)

      Akap200k07118a/Akap200[+] is a suppressor of inner nurse cell ring canal rim phenotype of Src64BPI

      (Jackson and Berg, 2002)
      Other
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The small ring canal phenotype see in Src64BPI homozygous females is dominantly suppressed by Akap200k07118a.

      The small ring canal phenotype seen in Src64BPI homozygous females is dominantly suppressed by Akap200k07118a.

      (Jackson and Berg, 2002)
      Xenogenetic Interactions
      Statement
      Reference

      30% of egg chambers have at least one binucleate nurse cell in Akap200k07118a/Df(2L)N22-14 females expressing Mmus\PkacamC.Scer\UAS under the control of Scer\GAL4nos.UTR.T:Hsim\VP16.

      (Jackson and Berg, 2002)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer

      Separable from: l(2)k07118bk07118b. The majority of the lethality of the original "l(2)k07118" chromosome is not due to the P{lacW}Akap200k07118a insertion, but is due to an unrelated background mutation (l(2)k07118bk07118b).

      (Jackson and Berg, 2002)
      Comments
      Comments

      Precise excision of the P{lacW} element reverts the Akap200k07118a mutant phenotypes.

      (Jackson and Berg, 2002)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Akap200k07118
      (Jackson and Berg, 2002)
      Akap200k07118a
      Name Synonyms
      Secondary FlyBase IDs
        References (1)