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General Information
Symbol
Dmel\Diap122-8S
Species
D. melanogaster
Name
FlyBase ID
FBal0146759
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Mutations Mapped to the Genome
     
    Type
    Location
    Additional Notes
    References
    Nucleotide change:

    G16038745A

    Amino acid change:

    C415Y | Diap1-PA; C415Y | Diap1-PB; C415Y | Diap1-PC; C415Y | Diap1-PD; C415Y | Diap1-PE; C415Y | Diap1-PF

    Reported amino acid change:

    C415Y

    Comment:

    Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

    Associated Sequence Data
    DNA sequence
    Protein sequence
     
     
    Progenitor genotype
    Cytology
    Nature of the lesion
    Statement
    Reference

    Amino acid replacement: C415Y.

    Expression Data
    Reporter Expression
    Additional Information
    Statement
    Reference
     
    Marker for
    Reflects expression of
    Reporter construct used in assay
    Human Disease Associations
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease-implicated variant(s)
     
    Phenotypic Data
    Phenotypic Class
    Phenotype Manifest In
    Detailed Description
    Statement
    Reference

    As early as 3 days after clone induction, no Diap122-8S mutant clones are observed in the female germline stem cell niche, while wild-type control clones are recovered in 15% of the germaria examined.

    Somatic clones of th22-8S homozygous cells in the wing disc express a cell death marker 18 hours after induction and are lost from the disc by 72 hours after induction. Despite this increased cell death, the resulting adults have normal wings.

    External Data
    Interactions
    Show genetic interaction network for Enhancers & Suppressors
    Phenotypic Class
    Phenotype Manifest In
    Additional Comments
    Genetic Interactions
    Statement
    Reference
    Xenogenetic Interactions
    Statement
    Reference

    Survival of th22-8S homozygous somatic clones induced in the posterior compartment of the wing disc is rescued by BacA\p35Scer\UAS.cHa; Scer\GAL4en-e16E. This is accompanied by an increase in proliferation of cells of the posterior compartment (as measure by BrdU incorporation), an effect seen most strongly in cells surrounding the clones. The resulting wing discs have a posterior compartment significantly larger than wild-type at late third instar.

    th22-8S homozygous somatic clones induced in the eye disc in the presence of BacA\p35Scer\UAS.cHa; Scer\GAL4ey.PH cause outgrowths in the adult eye.

    Complementation and Rescue Data
    Comments
    Images (0)
    Mutant
    Wild-type
    Stocks (0)
    Notes on Origin
    Discoverer
    External Crossreferences and Linkouts ( 0 )
    Synonyms and Secondary IDs (5)
    Reported As
    Symbol Synonym
    Diap122-8S
    diap122-8s
    th22-8S
    Name Synonyms
    Secondary FlyBase IDs
      References (3)