FlyBase Allele Report: Dmel\Snr1[cdel.3.UAS]

General Information

Symbol

Dmel\Snr1^cdel.3.UAS

Species

D. melanogaster

Name

FlyBase ID

FBal0147415

Feature type

allele

Associated gene

Dmel\Snr1

Associated Insertion(s)

Carried in Construct

P{UAS-snr1.cdel.3}

Key Links

Transgenic product class

inframe_deletion

(Zraly et al., 2003)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

inframe_deletion

(Zraly et al., 2003)

Mutagen

in vitro construct

(Brumby et al., 2002)

Progenitor genotype

Carried in construct

P{UAS-snr1.cdel.3}

Cytology

Description

UASt regulatory sequences drive expression of Snr1 amino acids 1-261. Snr1 5' UTR sequences are present.

(Zraly et al., 2003)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

Snr1

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

female sterile, with Scer\GAL4^Act5C.PI, Snr1^R3

(Zraly et al., 2003)

lethal, with Scer\GAL4^hs.PB

(Zraly et al., 2003)

lethal | heat sensitive, with Scer\GAL4^e22c, Snr1^R3

(Zraly et al., 2003)

short lived, with Scer\GAL4^Act5C.PI, Snr1^R3

(Zraly et al., 2003)

visible, with Scer\GAL4^69B

(Zraly et al., 2003)

visible, with Scer\GAL4^e22c

(Zraly et al., 2003)

Phenotype Manifest In

abdominal tergite, with Scer\GAL4^e22c

(Zraly et al., 2003)

abdominal tergite, with Scer\GAL4^e22c, Snr1^R3

(Zraly et al., 2003)

wing sensillum | ectopic, with Scer\GAL4^69B

(Zraly et al., 2003)

wing vein L2, with Scer\GAL4^69B

(Zraly et al., 2003)

Detailed Description

Statement

Reference

Expression of Snr1^{cdel.3.Scer\UAS} under the control of Scer\GAL4^en-e16E produces adult flies with apparently normal wings compared with wild-type flies.

(Herr et al., 2010)

Expression of Snr1^{cdel.3.Scer\UAS} under the control of Scer\GAL4^e22c results in incomplete abdominal tergite fusion along the dorsal midline. Expression of Snr1^{cdel.3.Scer\UAS} under the control of Scer\GAL4^69B in the wing results in the appearance of ectopic mechanosensory bristles, disruption of the L2 wing vein and an ectopic bristle on the distal portion of the L3 vein. Expression of Snr1^{cdel.3.Scer\UAS} under the control of Scer\GAL4^e22c in a Snr1^R3/+ background results in lethality at 29^oC, and significant cuticle disruption, including incomplete fusion of the abdominal tergites along the dorsal midline. More than 70% of females expressing Snr1^{cdel.3.Scer\UAS} under the control of Scer\GAL4^Act5C.PI in a Snr1^R3 background are sterile. Scer\GAL4^Act5C.PI/Snr1^{cdel.3.Scer\UAS};Snr1^R3 adults show a rapid decrease in viability following eclosion, with the effect being more pronounced among males.

(Zraly et al., 2003)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

Scer\GAL4^en-e16E, Snr1^cdel.3.UAS, geminin^UAS.cQa has visible phenotype

(Herr et al., 2010)

Phenotype Manifest In

Suppressor of

Statement

Reference

Scer\GAL4^Act5C.PI/Snr1^cdel.3.UAS is a suppressor of eye phenotype of CycE^JP

(Brumby et al., 2002)

Snr1^R3, Snr1^cdel.3.UAS, Scer\GAL4^69B is a suppressor of wing vein L5 phenotype of CycE^JP

(Brumby et al., 2002)

Snr1^R3, Scer\GAL4^Act5C.PI, Snr1^cdel.3.UAS is a suppressor of wing vein L5 phenotype of CycE^JP

(Brumby et al., 2002)

Snr1^R3, Snr1^cdel.3.UAS, Scer\GAL4^69B is a suppressor of wing phenotype of CycE^JP

(Brumby et al., 2002)

Snr1^R3, Scer\GAL4^Act5C.PI, Snr1^cdel.3.UAS is a suppressor of wing phenotype of CycE^JP

(Brumby et al., 2002)

Other

Statement

Reference

Scer\GAL4^en-e16E, Snr1^cdel.3.UAS, geminin^UAS.cQa has wing vein L5 phenotype

(Herr et al., 2010)

Additional Comments

Genetic Interactions

Statement

Reference

Co-expression of Snr1^{cdel.3.Scer\UAS} and geminin^Scer\UAS.cQa driven by Scer\GAL4^en-e16E causes a shortening of wing vein L5.

(Herr et al., 2010)

The CycE^JP rough eye phenotype is suppressed by the addition of Snr1^{cdel.3.Scer\UAS} driven by Scer\GAL4^Act5C.PI.

(Brumby et al., 2002)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Snr1^{cdel.3.Scer\UAS}

Snr1^cdel.3.UAS

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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