FlyBase Allele Report: Dmel\Myd88[c03881]

General Information

Symbol

Dmel\Myd88^c03881

Species

D. melanogaster

Name

FlyBase ID

FBal0147760

Feature type

allele

Associated gene

Dmel\Myd88

Associated Insertion(s)

PBac{PB}Myd88^c03881

Carried in Construct

Also Known As

dMyd88^c03881

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

piggyBac activity

Nature of the Allele

Allele class

Mutagen

piggyBac activity

(Kambris et al., 2003)

Progenitor genotype

Associated Insertion(s)

PBac{PB}Myd88^c03881

Cytology

Description

Insertion of PBac{PB} into the last intron of Myd88. Results in a chimaeric mRNA with the last exon of Myd88 is replaced by exons 2, 3 and 4 of the w gene. In the resulting protein the C-terminal extension is replaced by 39 random amino acids.

(Kambris et al., 2003)

Allele components

Component

Use(s)

Also carries

FRT

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

2R:9,304,530..9,304,530 [+]

(Caravello et al., 2022, Akhouayri et al., 2011, Kambris et al., 2003)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal immune response

(Marek and Kagan, 2012)

abnormal immune response | recessive

(Kambris et al., 2003)

female sterile

(Marek and Kagan, 2012)

female sterile | recessive

(Kambris et al., 2003)

lethal - all die during embryonic stage | maternal effect

(Kambris et al., 2003)

some die during embryonic stage | maternal effect

(Kambris et al., 2003)

Phenotype Manifest In

filzkorper

(Kambris et al., 2003)

ventral denticle belt

(Kambris et al., 2003)

Detailed Description

Statement

Reference

VA1d olfactory receptor neuron axon targeting is normal in mutant flies.

(Ward et al., 2015)

Mutant flies are highly susceptible to infection with either E. faecalis or S. epidermidis, resulting in rapid and complete lethality. The mutant flies are not sensitive to infection with E. coli.

(Marek and Kagan, 2012)

Inducible expression of Drs is strongly reduced in Myd88^c03881 mutants. Flies are highly susceptible to infection by fungi. Survival of adults is impaired. Embryos of mutant females are ventralised. Nuclear localization of dl, and twi expression, on ventral side of embryo fails.

(Kambris et al., 2003)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT suppressed by

Statement

Reference

Myd88^c03881 has lethal | maternal effect | embryonic stage phenotype, non-suppressible by Tl^10b

(Kambris et al., 2003)

Phenotype Manifest In

NOT suppressed by

Statement

Reference

Myd88^c03881 has ventral denticle belt phenotype, non-suppressible by Tl^10b

(Kambris et al., 2003)

Myd88^c03881 has filzkorper phenotype, non-suppressible by Tl^10b

(Kambris et al., 2003)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Myd88^c03881 is rescued by Scer\GAL4^hs.PU/Myd88^UAS.cMa

(Marek and Kagan, 2012)

Myd88^c03881 is rescued by Scer\GAL4^{VP16.mat.αTub67C}/Myd88^UAS.cMa

(Marek and Kagan, 2012)

Myd88^c03881 is rescued by Myd88^{UAS.Tag:PH(hPLCD1)}/Scer\GAL4^hs.PU

(Marek and Kagan, 2012)

Myd88^c03881 is rescued by Myd88^{UAS.Tag:PH(hPLCD1)}/Scer\GAL4^{VP16.mat.αTub67C}

(Marek and Kagan, 2012)

Myd88^c03881 is rescued by Scer\GAL4^{VP16.mat.αTub67C}/Myd88^UAS.JLI

(Kambris et al., 2003)

Myd88^c03881 is rescued by Scer\GAL4^unspecified/Myd88^UAS.JLI

(Kambris et al., 2003)

Partially rescued by

Myd88^c03881 is partially rescued by Scer\GAL4^hs.PU/Myd88^Cyto.UAS

(Marek and Kagan, 2012)

Not rescued by

Myd88^c03881 is not rescued by Scer\GAL4^{VP16.mat.αTub67C}/Myd88^Cyto.UAS

(Marek and Kagan, 2012)

Comments

Expression of Myd88^Scer\UAS.cMa or Myd88^{Scer\UAS.T:Hsap\PLCD1} under the control of Scer\GAL4^hs.PU rescues the susceptibility of Myd88^c03881 flies to infection with either E. faecalis or S. epidermidis.

Expression of Myd88^{Cyto.Scer\UAS} under the control of Scer\GAL4^hs.PU only partly rescues the susceptibility of Myd88^c03881 flies to infection with either E. faecalis or S. epidermidis.

Expression of Myd88^Scer\UAS.cMa or Myd88^{Scer\UAS.T:Hsap\PLCD1} under the control of Scer\GAL4^{mat.αTub67C.T:Hsim\VP16} restores female fertility in Myd88^c03881 flies.

Expression of Myd88^{Cyto.Scer\UAS} under the control of Scer\GAL4^{mat.αTub67C.T:Hsim\VP16} does not restore female fertility in Myd88^c03881 flies.

(Marek and Kagan, 2012)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Female fertility is restored on excision of the PBac{PB}.

(Kambris et al., 2003)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (9)

Reported As

Symbol Synonym

DmMyD88^PBc03881

(Kambris et al., 2003)

MyD88^c03881

(Xu et al., 2023, Caravello et al., 2022)

Myd88^PBc03881

Myd88^PBco3881

(Bischoff et al., 2004)

Myd88^c03881

(Lamiable et al., 2016, Bonnay et al., 2014)

c03881

(Marek and Kagan, 2012)

dMyD88^C03881

(Ward et al., 2015)

dMyd88⁰³⁸⁸¹

(Tavignot et al., 2017)

dMyd88^c03881

(Tavignot et al., 2017, Akhouayri et al., 2011)

Name Synonyms

Secondary FlyBase IDs

References (10)

Report Sections

Open Close