FB2026_03 , released September 17, 2026
Allele: Dmel\Gβ13FUAS.cFa
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General Information
Symbol
Dmel\Gβ13FUAS.cFa
Species
D. melanogaster
Name
FlyBase ID
FBal0147911
Feature type
allele
Associated gene
Dmel\Gβ13F
Associated Insertion(s)
Carried in Construct
P{UAS-Gβ13F.F}
Key Links
Transgenic product class
wild_type
(Fuse et al., 2003)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Fuse et al., 2003)
Mutagen
in vitro construct
(Fuse et al., 2003)
Progenitor genotype
Carried in construct
P{UAS-Gβ13F.F}
Cytology
Description

UASt sequences drive expression of Gβ13F.

(Fuse et al., 2003)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Gβ13F
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Overexpression of Gβ13FScer\UAS.cFa has no effect on neuroblast division.

      (Fuse et al., 2003)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Other
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Simultaneous expression of Gβ13FScer\UAS.cFa and Gγ1Scer\UAS.cFa (driven by Scer\GAL4mat.αTub67C.T:Hsim\VP16) drastically reduced microtubule organisation in the neuroblast. A metaphase mutant neuroblasts form a small symmetric or disorganised spindle, as though both spindle halves are basal. As a result, some telophase neuroblasts undergo equal cleavage, but others also frequently show defective cytokinesis. Gβ13FScer\UAS.cFa and Gγ1Scer\UAS.cFa simultaneously expressed in S2 cells (driven by Scer\GAL4Act5C.PHb) the mitotic spindle becomes shrunken.

      (Fuse et al., 2003)

      Simultaneous expression of Gβ13FScer\UAS.cFa and Gγ1Scer\UAS.cFa (driven by Scer\GAL4mat.αTub67C.T:Hsim\VP16) drastically reduces microtubule organisation in the neuroblast. At metaphase, mutant neuroblasts form a small symmetric or disorganised spindle, as though both spindle halves are basal. As a result, some telophase neuroblasts undergo equal cleavage, but others also frequently show defective cytokinesis. When Gβ13FScer\UAS.cFa and Gγ1Scer\UAS.cFa are simultaneously expressed in S2 cells (driven by Scer\GAL4Act5C.PHb), the mitotic spindle becomes shrunken.

      (Fuse et al., 2003)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      Scer\GAL4pros.PMG/Gβ13FUAS.cFa partially rescues Gβ13Ff261

      (Fuse et al., 2003)
      Comments

      Gβ13FScer\UAS.cFa driven by Scer\GAL4pros.PMG rescues the neuroblast phenotypes but not the gastrulation defects.

      (Fuse et al., 2003)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Gβ13FScer\UAS.cFa
      Gβ13FUAS.cFa
      Name Synonyms
      Secondary FlyBase IDs
        References (3)