FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\eRF3LR16
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General Information
Symbol
Dmel\eRF3LR16
Species
D. melanogaster
Name
FlyBase ID
FBal0147918
Feature type
allele
Associated gene
Dmel\eRF3
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Bejsovec, 2003.6.3, Chao et al., 2003)
Progenitor genotype
Cytology
Description

Amino acid replacement: G282D.

(Chao et al., 2003)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2L:12,438,303..12,438,303 [+]
Nucleotide change:

G12438303A

Amino acid change:

G282D | eRF3-PA; G282D | eRF3-PB; G158D | eRF3-PC; G282D | eRF3-PD

Reported amino acid change:

G282D

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Chao et al., 2003)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygotes appear morphologically normal, but die after several days during the first instar.

      (Chao et al., 2003)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Nonsense suppressor of the wgPE4 mutation.

      (Bejsovec, 2003.6.3)

      The lawn of denticles phenotype seen in homozygous wgPE4 embryos at 25oC is suppressed by ElfLR16. This effect is a dominant maternal effect; wgPE4 homozygous embryos laid by a female heterozygous for wgPE4 and ElfLR16 show suppression of the wgPE4 phenotype, whether or not the male parent carries ElfLR16. The wgPE4 phenotype is suppressed more completely in wgPE4 homozygous embryos derived from females carrying both eRF1KY7 and ElfLR16. The cuticle phenotype of wgPE13 homozygous embryos is not suppressed if their female parent is heterozygous for ElfLR16. Embryos derived from females homozygous for wgPE4.Scer\UAS.cCa.T:Ivir\HA1 and heterozygous for ElfLR16 crossed to males homozygous for Scer\GAL4e22c produce excess naked cuticle.

      (Chao et al., 2003)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer

      Induced on: a wgPE4 chromosome.

      (Chao et al., 2003)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      ElfLR16
      (Christensen et al., 2008.4.15)
      eRF3LR16
      (Bejsovec, 2003.6.3, Chao et al., 2003)
      Name Synonyms
      Secondary FlyBase IDs
        References (4)