FlyBase Allele Report: Dmel\Usp7[KG06814]

General Information

Symbol

Dmel\Usp7^KG06814

Species

D. melanogaster

Name

FlyBase ID

FBal0148297

Feature type

allele

Associated gene

Dmel\Usp7

Associated Insertion(s)

P{SUPor-P}Usp7^KG06814

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Gene Disruption Project members, 2001-)

Progenitor genotype

Associated Insertion(s)

P{SUPor-P}Usp7^KG06814

Cytology

Description

Allele components

Component

Use(s)

Inserted element

P{SUPor-P}

insertional mutagenesis tool

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

X:12,028,431..12,028,431 [+]

(Sun et al., 2019, Gene Disruption Project members, 2001-)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal

(Lake et al., 2024)

lethal | male

(van der Knaap et al., 2005)

Phenotype Manifest In

Detailed Description

Statement

Reference

Usp7^KG06814 is a lethal mutation in males and homozygous lethal in females.

(van der Knaap et al., 2005)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Usp7^KG06814/Usp7[+] is an enhancer of visible phenotype of Scer\GAL4^GMR.PF, bchs^EP2299

(Simonsen et al., 2007)

Usp7^KG06814/Usp7[+] is an enhancer of visible | homeotic | female phenotype of Pc¹

(van der Knaap et al., 2005)

Phenotype Manifest In

Enhancer of

Statement

Reference

Usp7^KG06814/Usp7[+] is an enhancer of eye phenotype of Scer\GAL4^GMR.PF, bchs^EP2299

(Simonsen et al., 2007)

Usp7^KG06814/Usp7[+] is an enhancer of haltere | ectopic | female phenotype of Pc¹

(van der Knaap et al., 2005)

Usp7^KG06814/Usp7[+] is an enhancer of wing | female phenotype of Pc¹

(van der Knaap et al., 2005)

Usp7^KG06814/Usp7[+] is an enhancer of haltere | ectopic | female phenotype of Pc³

(van der Knaap et al., 2005)

Usp7^KG06814/Usp7[+] is an enhancer of wing | female phenotype of Pc³

(van der Knaap et al., 2005)

Other

Statement

Reference

Pc³, Usp7^KG06814/Usp7[+] has leg | ectopic | female phenotype

(van der Knaap et al., 2005)

Pc³, Usp7^KG06814 has antenna | female phenotype

(van der Knaap et al., 2005)

Pc³, Usp7^KG06814 has leg | ectopic | female phenotype

(van der Knaap et al., 2005)

Pc³, Usp7^KG06814/Usp7[+] has antenna | female phenotype

(van der Knaap et al., 2005)

Additional Comments

Genetic Interactions

Statement

Reference

Females transheterozygous for Usp7^KG06814 and Pc³ show antenna to leg transformations, which are not observed in Pc³ flies. Usp7^KG06814 strongly enhances the frequency and severity of a range of homeotic transformations caused by either Pc¹ or Pc³ flies. In combination with either hetero- (females) or hemizygous (males) Pc¹ or Pc³ flies, Usp7^KG06814 significantly increases the penetrance of wing-to-haltere transformations. Depending on the combination of alleles, wing-to-haltere transformations occur in the majority or virtually all animals. Likewise, there is a strong increase in the frequency and extent of transformations of the fourth abdominal segment (A4) into the semblance of the fifth (A5), indicated by increased dark pigmentation of the A4.

(van der Knaap et al., 2005)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

14505

y¹ P{SUPor-P}Usp7^KG06814/FM7c, sn⁺

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

CG1490^KG06814

Pusp7^KG06814

(Lake et al., 2024)

Usp7^KG06814

(Derkacheva et al., 2016, Popodi et al., 2010-, van der Knaap et al., 2010)

usp7^KG06814

(Sun et al., 2019)

Name Synonyms

Secondary FlyBase IDs

References (8)

Report Sections

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