FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\AP-2αear5
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General Information
Symbol
Dmel\AP-2αear5
Species
D. melanogaster
Name
FlyBase ID
FBal0148524
Feature type
allele
Associated gene
Dmel\AP-2α
Associated Insertion(s)
Carried in Construct
Also Known As
adaear5
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Berdnik et al., 2002)
Progenitor genotype
Cytology
Description

Amino acid replacement: Q850term.

(Berdnik et al., 2002)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2L:409,729..409,729 [-]
Nucleotide change:

C409729T

Reported nucleotide change:

C?T

Amino acid change:

Q850term | AP-2alpha-PA; Q862term | AP-2alpha-PB

Reported amino acid change:

Q850term

(Berdnik et al., 2002)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      α-Adaptinear5 mutants show cell fate transformation in external sensory organs. The phenotype manifests as multiple sockets in the sensory organ mother cell (SOP) lineage. α-Adaptinear5 mutants do not show neuroblast overproliferation.

      (Song and Lu, 2012)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Complements

      AP-2α06694

      (Berdnik et al., 2002)
      Fails to complement

      AP-2α3

      (Berdnik et al., 2002)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      AP-2αear5
      adaear5
      (Song and Lu, 2012, Roegiers et al., 2005, Berdnik et al., 2002)
      α-Adaptinear5
      Name Synonyms
      Secondary FlyBase IDs
        References (3)