Heterozygosity for AP-2α3 enhances the ddaC neuron pruning defects observed in prd1M56/Df(3R)Exel7310 transheterozygous or upon expression of unc-104GD16406 under the control of Scer\GAL4ppk.PU (and Dicer-2, for efficient RNAi); specifically, the persisting dendrites become significantly longer.
α-Adaptin3/+ enhances the reduction in the number of dendritic endpoints of dorsal dendritic arborisation neurons which is seen in larvae expressing NakdsRNA.Scer\UAS under the control of Scer\GAL4elav-C155. In addition, clusters of shortened terminals are more often seen.
Double heterozygotes of α-Adaptin3/+ with Chc1/+ have a reduced wing with vein defects at 25oC and the wing remnant phenotype at 29oC. Double heterozygotes of α-Adaptin3/+ with Chc1/+ at 18oC show a thickened posterior crossvein phenotype, reminiscent of the tkv mutant phenotype.