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General Information
Symbol
Dmel\unc-104GD16406
Species
D. melanogaster
Name
FlyBase ID
FBal0210832
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UASt regulatory sequences drive expression of an inverted repeat.

Allele components
Product class / Tool use(s)
Encoded product / tool
Associated Sequence Features
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of unc-104GD16406 under the control of Scer\GAL4ppk.PU (and Dicer-2, for efficient RNAi) induces severe and fully penetrant ddaC neuron dendrite pruning defects at 16h after puparium formation, as compared to controls; these neurons do not present any obvious changes in lysosomes (i.e. Lysotracker staining), secretory vesicles (Sec15) or Golgi apparatus (i.e. GalT), as compared to controls.

Larval ddaE neurons expressing unc-104GD16406 under the control of Scer\GAL4221 (and Dicer-2, for a more efficient RNAi) show a significant increase in growing microtubules within dendrites, as compared to neurons in controls.

External Data
Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

The ddaC neuron pruning defects induced by the expression of unc-104GD16406 under the control of Scer\GAL4ppk.PU (and Dicer-2, for efficient RNAi) are significantly enhanced by heterozygosity for AP-2α3, as the persisting dendrites become significantly longer.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (2)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 1 )
Crossreferences
Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
unc-104GD16406
Name Synonyms
Secondary FlyBase IDs
    References (6)