FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Tsc1UAS.Tag:MYC
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General Information
Symbol
Dmel\Tsc1UAS.Tag:MYC
Species
D. melanogaster
Name
FlyBase ID
FBal0150577
Feature type
allele
Associated gene
Dmel\Tsc1
Associated Insertion(s)
Carried in Construct
P{UAS-Tsc1.MYC}
Also Known As
UAS-Tsc1
Key Links
Transgenic product class
wild_type
(Potter et al., 2002)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Potter et al., 2002)
Mutagen
in vitro construct
(Potter et al., 2002)
Progenitor genotype
Carried in construct
P{UAS-Tsc1.MYC}
Cytology
Description

UAS sequences drive expression of Tsc1 fused at the C-terminus to 6 copies of the epitope tag Tag:MYC.

(Potter et al., 2002)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Tsc1
Tagged with
Tag:MYC
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Scer\GAL4GMR.long>Tsc1Scer\UAS.T:Hsap\MYC mutants show no defects in opsin regulation.

      (Mikeladze-Dvali et al., 2005)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhancer of
      Suppressor of
      NOT Suppressor of
      Statement
      Reference

      Tsc1UAS.Tag:MYC, Scer\GAL4GMR.PF is a non-suppressor of ommatidium phenotype of AktUAS.Tag:HA, Scer\GAL4GMR.PF

      (Potter et al., 2002)
      Other
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      gigScer\UAS.T:Zzzz\FLAG/Scer\GAL4ey.PH; Tsc1Scer\UAS.T:Hsap\MYC/+ flies have small eyes with a 31% decrease in ommatidia numbers compared to wild-type. gigΔAkt-P.Scer\UAS.T:Zzzz\FLAG/Scer\GAL4ey.PH; Tsc1Scer\UAS.T:Hsap\MYC/+ flies have small eyes with a 75% decrease in ommatidia numbers compared to wild-type. gigS924A.Scer\UAS.T:Zzzz\FLAG/Scer\GAL4ey.PH; Tsc1Scer\UAS.T:Hsap\MYC/+ flies have small eyes with an approximately 45% decrease in ommatidia numbers compared to wild-type. gigT1518A.Scer\UAS.T:Zzzz\FLAG/Scer\GAL4ey.PH; Tsc1Scer\UAS.T:Hsap\MYC/+ flies have small eyes with a approximately 45% decrease in ommatidia numbers compared to wild-type. gigS924A.T1518A.Scer\UAS.T:Zzzz\FLAG/Scer\GAL4ey.PH; Tsc1Scer\UAS.T:Hsap\MYC/+ flies have small eyes with a 75% decrease in ommatidia numbers compared to wild-type. gigT437A.T1054A.Scer\UAS.T:Zzzz\FLAG/Scer\GAL4ey.PH; Tsc1Scer\UAS.T:Hsap\MYC/+ flies have small eyes with a 31% decrease in ommatidia numbers compared to wild-type (i.e.- results with this mutated gig are no different to those with wild-type gig.) The increase in ommatidial size seen in Akt1Scer\UAS.T:Ivir\HA1; Scer\GAL4GMR.PF flies is: unaffected by Tsc1Scer\UAS.T:Hsap\MYC alone; partially suppressed by gigScer\UAS.T:Zzzz\FLAG with Tsc1Scer\UAS.T:Hsap\MYC; and fully suppressed by gigΔAkt-P.Scer\UAS.T:Zzzz\FLAG with Tsc1Scer\UAS.T:Hsap\MYC. In this latter case of full suppression, ommatidial size is actually reduced slightly (by 14%) compared to wild-type. Wing margin bristles in somatic clones of gigScer\UAS.T:Zzzz\FLAG/Scer\GAL4Act5C.PI; Tsc1Scer\UAS.T:Hsap\MYC/+ exhibit an average size decrease of 35%. The increase in wing margin bristle size seen in Akt1Scer\UAS.T:Ivir\HA1; Scer\GAL4Act5C.PI somatic clones is partially suppressed by gigScer\UAS.T:Zzzz\FLAG with Tsc1Scer\UAS.T:Hsap\MYC, but is fully suppressed by gigΔAkt-P.Scer\UAS.T:Zzzz\FLAG with Tsc1Scer\UAS.T:Hsap\MYC.

      (Potter et al., 2002)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Carried in the plasmid "pRmHa-3-Tsc1-Myc", transfected into S2 cells.

      (Potter et al., 2002)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Tsc1Scer\UAS.T:Hsap\MYC
      Tsc1UAS.Tag:MYC
      Name Synonyms
      Secondary FlyBase IDs
        References (2)