FlyBase Allele Report: Dmel\Mhc[2F]

General Information

Symbol

Dmel\Mhc^2F

Species

D. melanogaster

Name

FlyBase ID

FBal0150762

Feature type

allele

Associated gene

Dmel\Mhc

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Nongthomba et al., 2003)

Progenitor genotype

Cytology

Description

Nucleotide substitution: G?A. Amino acid replacement: A462T.

(Nongthomba et al., 2003)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

2L:16,774,837..16,774,837 [+]

Nucleotide change:

G16774837A

Reported nucleotide change:

G?A

Amino acid change:

Reported amino acid change:

A462T

(Nongthomba et al., 2003)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

flightless | dominant

(Nongthomba et al., 2003)

lethal (with Df(2L)H20)

(Nongthomba et al., 2003)

lethal (with Mhc¹)

(Nongthomba et al., 2003)

lethal | recessive

(Nongthomba et al., 2003)

visible | dominant

(Nongthomba et al., 2003)

Phenotype Manifest In

wing

(Nongthomba et al., 2003)

Detailed Description

Statement

Reference

8% of heterozygous flies have an upheld wings phenotype.

(Nongthomba et al., 2003)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Mhc[+]/Mhc^2F is a suppressor of visible phenotype of up¹⁰¹

(Nongthomba et al., 2003)

Mhc[+]/Mhc^2F is a suppressor of abnormal locomotor behavior phenotype of wupA^hdp-2

(Nongthomba et al., 2003)

Mhc[+]/Mhc^2F is a suppressor of visible phenotype of wupA^hdp-2

(Nongthomba et al., 2003)

NOT Suppressor of

Statement

Reference

Mhc¹²/Mhc^2F is a non-suppressor of visible phenotype of wupA^hdp-3

(Nongthomba et al., 2003)

Phenotype Manifest In

Suppressor of

Statement

Reference

Mhc¹²/Mhc^2F is a suppressor of indirect flight muscle cell phenotype of wupA^hdp-3

(Nongthomba et al., 2003)

Mhc[+]/Mhc^2F is a suppressor of indirect flight muscle cell phenotype of up¹⁰¹

(Nongthomba et al., 2003)

Mhc[+]/Mhc^2F is a suppressor of wing phenotype of up¹⁰¹

(Nongthomba et al., 2003)

Mhc[+]/Mhc^2F is a suppressor of indirect flight muscle cell phenotype of wupA^hdp-2

(Nongthomba et al., 2003)

Mhc[+]/Mhc^2F is a suppressor of wing phenotype of wupA^hdp-2

(Nongthomba et al., 2003)

NOT Suppressor of

Statement

Reference

Mhc¹²/Mhc^2F is a non-suppressor of indirect flight muscle cell phenotype of wupA^hdp-3

(Nongthomba et al., 2003)

Mhc¹²/Mhc^2F is a non-suppressor of wing phenotype of wupA^hdp-3

(Nongthomba et al., 2003)

Additional Comments

Genetic Interactions

Statement

Reference

The defects seen in wupA^hdp-2/Y flies are partially suppressed by Mhc^2F/+; 28% of the double mutant adults have an upheld wing phenotype and 72% hold their wings in the normal position. 11% of the indirect flight muscle fibres show a partial hypercontraction phenotype and 89% are normal. Sarcomere structure is comparable to wild type in these flies, but sarcomere length is significantly shorter than normal, and a few days after eclosion muscle fibres become thin in many areas and contract. The indirect flight muscles of wupA^hdp-3/Y ; Mhc¹²/Mhc^2F flies show a partial hypercontraction phenotype.

(Nongthomba et al., 2003)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

Mhc¹

(Nongthomba et al., 2003)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Selected as: a dominant suppressor of the wupA^hdp-2 wings-up phenotype.

(Nongthomba et al., 2003)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Mhc^2F

Su(2)F

(Nongthomba et al., 2003)

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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