FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\unc-454F2-4
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General Information
Symbol
Dmel\unc-454F2-4
Species
D. melanogaster
Name
FlyBase ID
FBal0151622
Feature type
allele
Associated gene
Dmel\unc-45
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Martin et al., 2003)
Progenitor genotype
Cytology
Description

Amino acid replacement: Q573term.

(Doerflinger et al., 2022)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:8,035,374..8,035,374 [+]
Nucleotide change:

C8035374T

Amino acid change:

Q572term | unc-45-PA; Q572term | unc-45-PB

Reported amino acid change:

Q573term

Comment:

The mutation is reported as a Q573term mutation. There is no Gln at position 573 in the reference sequence and the nonsense mutation was mapped to Q572. Site and nature of nucleotide substitution in mutant inferred by FlyBase curator based on reported amino acid change.

(Doerflinger et al., 2022)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Oocytes from unc-454F2-4 germline clones exhibit polarity defects (e.g. Staufen protein and oskar mRNA not localized at all, or weekly localized; mislocalized Par-1 protein; disrupted microtubule cytoskeleton polarity; mislocalized nucleus).

      (Doerflinger et al., 2022)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      unc-4503692

      (Doerflinger et al., 2022)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Selected as: a mutant that results in defective localisation of an Avic\GFP-stau marker in living oocytes in females containing homozygous germ-line clones.

      (Martin et al., 2003)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      poulpe4F2-4
      (Doerflinger et al., 2022)
      pup4F2-4
      unc-454F2-4
      (Doerflinger et al., 2022)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)