FB2026_02 , released June 18, 2026
Allele: Dmel\unc-4503692
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General Information
Symbol
Dmel\unc-4503692
Species
D. melanogaster
Name
FlyBase ID
FBal0009482
Feature type
allele
Associated gene
Dmel\unc-45
Associated Insertion(s)
P{PZ}unc-4503692
Carried in Construct
Also Known As
Tom3403692
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
Progenitor genotype
Associated Insertion(s)
P{PZ}unc-4503692
Cytology
Description
Allele components
Component
Use(s)
Inserted element
P{PZ}
Encoded product / tool
lacZ
Tagged with
Tag:NLS(P)
Mutations Mapped to the Genome
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      exacerbates  tauopathy
      modeled by Hsap\MAPTGMR.Ex.PJ
      (Ambegaokar and Jackson, 2011)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      unc-4503692 mutants do not display a wing phenotype.

      (Colin et al., 2009)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      unc-4503692/unc-45[+] is an enhancer of visible phenotype of Hsap\MAPTGMR.Ex.PJ

      (Ambegaokar and Jackson, 2011)

      unc-4503692/unc-45[+] is an enhancer of increased cell death phenotype of Mmus\BaxUAS.cGa, Scer\GAL4vg.PM

      (Colin et al., 2009)
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      unc-4503692/unc-45[+] is an enhancer of eye phenotype of Hsap\MAPTGMR.Ex.PJ

      (Ambegaokar and Jackson, 2011)

      unc-4503692/unc-45[+] is an enhancer of wing phenotype of Mmus\BaxUAS.cGa, Scer\GAL4vg.PM

      (Colin et al., 2009)

      unc-4503692/unc-45[+] is an enhancer of wing margin phenotype of Mmus\BaxUAS.cGa, Scer\GAL4vg.PM

      (Colin et al., 2009)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      One copy of unc-4503692 enhances the rough eye phenotype seen in flies expressing Hsap\MAPTGMR.Ex.PJ.

      (Ambegaokar and Jackson, 2011)

      A unc-4503692 heterozygous background enhances the wing phenotypes found upon expression of Mmus\BaxScer\UAS.cGa in the wing under the control of Scer\GAL4vg.PM. There is a significant increase from 60% to 90% of strong phenotypes (compared to controls) and a decrease from 40% to 10% of intermediate phenotypes. This shift in phenotype distribution reflects an enhancement of the Mmus\BaxScer\UAS.cGa-induced phenotype thus showing an increase of Mmus\BaxScer\UAS.cGa-induced cell death.

      (Colin et al., 2009)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer

      A. Spradling.

      Comments
      Comments

      Complements: AtpĪ±01278. Complements: l(3)0273202732. Complements: l(3)j15E7j15E7. Complements: l(3)j4E1j4E1. Complements: lap1. Complements: l(3)neo351.

      (BDGP Project Members, 1994-1999)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      References (10)