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Citation
Colin, J., Garibal, J., Mignotte, B., GuĂ©nal, I. (2009). The mitochondrial TOM complex modulates bax-induced apoptosis in Drosophila.  Biochem. Biophys. Res. Commun. 379(4): 939--943.
FlyBase ID
FBrf0206834
Publication Type
Research paper
Abstract

Bax is a pro-apoptotic member of the Bcl-2 family proteins involved in the release of apoptogenic factors from mitochondria to the cytosol. Recently, it has been shown both in mammals and yeast that Bax insertion in the mitochondrial outer membrane involves at least two distinct mechanisms, one of which uses the TOM complex. Here, we show that in Drosophila, heterozygous loss of function mutations of Tom22 or Tom70, two receptors of the TOM complex, attenuates bax-induced phenotypes in vivo. These results argue that the TOM complex may be used as a mitochondrial Bax receptor in Drosophila.

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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Biochem. Biophys. Res. Commun.
    Title
    Biochemical and Biophysical Research Communications
    Publication Year
    1959-
    ISBN/ISSN
    0006-291X
    Data From Reference
    Alleles (7)
    Genes (6)
    Insertions (3)
    Transgenic Constructs (3)