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General Information
Symbol
Dmel\lsn5F3-8
Species
D. melanogaster
Name
FlyBase ID
FBal0151741
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Nucleotide change:

C21865281T

Amino acid change:

R2term | lsn-PA

Reported amino acid change:

R2term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Amino acid replacement: R2term.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

lsn5F3-8 somatic clones in eye-antennal imaginal discs contain enlarged, abnormal early endosomes.

lsn5F3-8 somatic clones in eye-antennal imaginal discs show high levels of apoptosis compared to wildtype. However, non-autonomous overgrowth of the eye-antennal imaginal disc, adult eye and head occurs these animals.

When the majority of cells in the eye-antennal imaginal discs are mutant for lsn5F3-8, striking tissue overgrowth of the disc occurs and loose cellular architecture is observed.

lsn5F3-8 mutant somatic clones in eye-antennal imaginal discs do not proliferate very well, however the wildtype tissue immediately adjacent to the mutant clones show increased cell proliferation rates.

Females with homozygous germline clones do not lay eggs.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Suppressed by
Statement
Reference

lsn5F3-8 has eye | somatic clone phenotype, suppressible by N264-39

lsn5F3-8 has adult head | somatic clone phenotype, suppressible by N264-39

NOT Suppressor of
Statement
Reference

lsn5F3-8 is a non-suppressor | somatic clone of eye phenotype of hidGMR.PG/WGMR.PG

Additional Comments
Genetic Interactions
Statement
Reference

Heterozygosity for N264-39 suppresses the overgrowth of the adult eye and head that occurs in animals with somatic clones of lsn5F3-8 generated in the eye-antennal disc.

The eye-ablation phenotype in WGMR.PG animals is not suppressed in lsn5F3-8 somatic clones generated in the eye-antennal imaginal disc.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer

Selected as: a mutant that results in defective localisation of an Avic\GFP-stau marker in living oocytes in females containing homozygous germ-line clones.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (4)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (5)