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General Information
Symbol
Dmel\fraunspecified
Species
D. melanogaster
Name
FlyBase ID
FBal0151924
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Mutations Mapped to the Genome
     
    Type
    Location
    Additional Notes
    References
    Associated Sequence Data
    DNA sequence
    Protein sequence
     
     
    Progenitor genotype
    Cytology
    Nature of the lesion
    Statement
    Reference
    Expression Data
    Reporter Expression
    Additional Information
    Statement
    Reference
     
    Marker for
    Reflects expression of
    Reporter construct used in assay
    Human Disease Associations
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Disease
    Interaction
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    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease-implicated variant(s)
     
    Phenotypic Data
    Phenotypic Class
    Phenotype Manifest In
    Detailed Description
    Statement
    Reference

    fraunspecified mutants display EW axon guidance defects.

    fraunspecified embryos show SP1 axon midline crossing defects and SP1 cell body migration defects.

    The Fas2-positive longitudinal tracts are positioned farther apart from the midline than normal in mutant embryos.

    The nerve cord has missing or reduced commissural tracts in mutant 14 hour embryos and commissural defects are seen in every segment. The longitudinal connectives are farther away from the midline than normal; the medial tracts are positioned about 18μm apart in 14 hour mutant embryos, compared to about 9 μm apart in wild-type embryos. Earlier in development, at approximately 10 hours, the tracts from pCC neurons are projected farther away from the midline than normal.

    fraunspecified mutants show trajectory defects of the ISN; this fascicle stalls, show excessive branching, crosses segment boundaries and projects beyond the dorsal target muscles. The ventral ISNb innervation of muscles 6 and 7 is disrupted but SNa innervations are normal.

    Mutant embryos show a range of defects in central nervous system axon guidance.

    External Data
    Interactions
    Show genetic interaction network for Enhancers & Suppressors
    Phenotypic Class
    Phenotype Manifest In
    Additional Comments
    Genetic Interactions
    Statement
    Reference

    Expression of commScer\UAS.cKa under the control of Scer\GAL4eg-Mz360 partially suppresses the EW axon guidance defects in fraunspecified mutants.

    The EW neuron guidance defects in fraunspecified robo1 double mutants are less severe than fraunspecified single mutants.

    The severity of the SP1 axon midline crossing defects seen in fraunspecified embryos is enhanced in fraunspecified Dscam05518 Dscam3c02826 triple mutants.

    robo4, fraunspecified double mutant embryos show a mixture of longitudinal tract phenotypes, ranging from a phenotype like that seen in the robo4 single mutant (collapsed tracts) to a phenotype like that seen in the fraunspecified single mutant (tracts positioned further away from the midline than normal) and an intermediate phenotype, although the robo-like phenotype is predominant.

    When RhoGAP93BdsRNA.Scer\UAS is driven by Scer\GAL4elav.PLu in a fraunspecified background no midline crossing defects are seen

    Removal of a single copy of the fra gene leads to a threefold reduction in the number of midline crossovers induced by Gα49BQ203L.Scer\UAS under the control of Scer\GAL4elav-C155 (from 48.10% to 15.3% of abdominal segments exhibit midline crossing). A further reduction is observed upon removal of both copies of the fra gene in Scer\GAL4elav-C155/Gα49BQ203L.Scer\UAS;fra3/fra4, from 48.10% of abdominal segments exhibiting midline crossover in Scer\GAL4elav-C155/Gα49BQ203L.Scer\UAS embryos to 5.3% in Scer\GAL4elav-C155/Gα49BQ203L.Scer\UAS;fra3/fra4 mutant embryos.

    Gef64Cunspecified enhances the axon guidance defects seen in fraunspecified embryos; there is a substantial reduction in commissure thickness and a greater number of segments where commissures fail to form.

    Xenogenetic Interactions
    Statement
    Reference
    Complementation and Rescue Data
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    Mutant
    Wild-type
    Stocks (0)
    Notes on Origin
    Discoverer
    External Crossreferences and Linkouts ( 0 )
    Synonyms and Secondary IDs (2)
    Reported As
    Symbol Synonym
    fraunspecified
    Name Synonyms
    Secondary FlyBase IDs
      References (9)